Oravec P L, Parrott E L
J Pharm Sci. 1985 Feb;74(2):175-9. doi: 10.1002/jps.2600740214.
A chemical reaction, diffusion, and ionization model, which assumes the establishment of ionization equilibrium at an equilibrium plane located within the diffusion layer, is tested by use of experimental dissolution rates for some oxygen acids and carbon acids. For oxygen acids both two- and three-zone models predict observed dissolution rates; however, for barbituric acid dihydrate and phenylbutazone neither model successfully depicts the dissolution behavior. Although the three-zone model approximately predicts dissolution rates of oxygen acids, its complexity does not add to the accuracy of the calculated rate. The three-zone model does support the frequent assumption that ionization is instantaneous and can be ignored in modeling.
一种化学反应、扩散和电离模型，该模型假定在位于扩散层内的平衡平面处建立电离平衡，通过使用某些含氧酸和碳酸的实验溶解速率对其进行了测试。对于含氧酸，两区和三区模型均能预测观察到的溶解速率；然而，对于巴比妥酸二水合物和保泰松，两种模型均未能成功描述其溶解行为。尽管三区模型大致能预测含氧酸的溶解速率，但其复杂性并未提高计算速率的准确性。三区模型确实支持了一种常见的假设，即电离是瞬间发生的，在建模时可以忽略不计。
