Ibrahim H G, Pisano F, Bruno A
J Pharm Sci. 1977 May;66(5):669-73. doi: 10.1002/jps.2600660515.
Data from X-ray diffraction, thermal analysis, IR spectroscopy, and solubility studies were used for the identification and characterization of four crystalline modifications of phenylbutazone. The thermal behavior of the polymorphs under different treatment conditions also was investigated. Compression of the thermodynamically unstable forms, at a compression force of 1590--2040 kg, induced polymorphic changes in the crystals. Similar changes also were produced through grinding. The apparent equilibrium solubilties of polymorphs were determined, as was the dissolution of the polymorphs as compressed disks in an aqueous medium. The small effective surface area possessed by one polymorph resulted in slow dissolution.
利用X射线衍射、热分析、红外光谱和溶解度研究的数据对保泰松的四种晶型进行鉴定和表征。还研究了不同处理条件下多晶型物的热行为。在1590 - 2040 kg的压力下压缩热力学不稳定形式会引起晶体的多晶型变化。研磨也会产生类似的变化。测定了多晶型物的表观平衡溶解度，以及多晶型物作为压缩盘在水介质中的溶解情况。一种多晶型物具有较小的有效表面积，导致溶解缓慢。
