Hyakusoku Hiroshi, Mori Yoshiaki, Yakeishi Mayumi, Kamoshida Risa, Nakayama Meijin
Otolaryngology, Yokosuka Kyosai Hospital, Yokosuka, JPN.
Pathology, Yokosuka Kyosai Hospital, Yokosuka, JPN.
Cureus. 2025 Jan 2;17(1):e76779. doi: 10.7759/cureus.76779. eCollection 2025 Jan.
Benign symmetric lipomatosis (BSL) is a rare disorder that is characterized by diffuse growth, multiple symmetrical accumulation, and unencapsulated lipomas. BSL is also known as Madelung disease, Launois-Bensaude syndrome, and multiple symmetric lipomatosis. BSL is commonly found in the upper trunk and posterior neck. Symmetric lipomatosis of the tongue (SLT) is extremely rare. A 49-year-old man with a history of primary biliary cholangitis, hypertension, and gastroduodenal ulcer, as well as a background of heavy alcohol consumption, was referred to our department due to a one-month history of difficulties in speaking and swallowing and dysgeusia. Bilateral adipose tissue in the tongue was observed. His dysgeusia improved immediately after glossectomy. A literature review of case reports of SLT was performed using PubMed and Web of Science. A total of 62 articles were extracted. We reviewed 17 articles comprising 18 patients (15 men and three women) who met the inclusion criteria. Including our patient, the age at diagnosis ranged from 49 to 88 years old, with a median age of 66.5 years old. The rates of alcohol consumption and type of BSL (I/II) were 42.1% and 84.2%, respectively. The rates of dysphasia, dysarthria, and dyspnea symptoms were 55.6%, 66.7%, and 27.8%, respectively. Fourteen patients underwent glossectomy. Dysgeusia caused by SLT may improve with glossectomy. 'Wait-and-see' may be an option unless patients complain of symptoms such as dysphasia, dysarthria, and dyspnea. As lipomatosis has the potential for regrowth and SLT can transform into a malignant tumor, long-term follow-up is necessary.
良性对称性脂肪瘤病（BSL）是一种罕见的疾病，其特征为弥漫性生长、多个对称性堆积以及无包膜的脂肪瘤。BSL也被称为马德隆病、劳诺瓦 - 本索德综合征和多发性对称性脂肪瘤病。BSL常见于上躯干和后颈部。舌部对称性脂肪瘤病（SLT）极为罕见。一名49岁男性，有原发性胆汁性胆管炎、高血压和胃十二指肠溃疡病史，且有大量饮酒史，因有一个月的说话和吞咽困难及味觉障碍病史而被转诊至我科。观察到其舌部双侧有脂肪组织。舌切除术后其味觉障碍立即改善。使用PubMed和科学网对SLT病例报告进行了文献综述。共提取到62篇文章。我们回顾了17篇文章，其中包含18例符合纳入标准的患者（15例男性和3例女性）。包括我们的患者在内，诊断时的年龄范围为49至88岁，中位年龄为66.5岁。饮酒率和BSL类型（I/II）分别为42.1%和84.2%。吞咽困难、构音障碍和呼吸困难症状的发生率分别为55.6%、66.7%和27.8%。14例患者接受了舌切除术。SLT引起的味觉障碍可能通过舌切除术改善。除非患者出现吞咽困难、构音障碍和呼吸困难等症状，“观察等待”可能是一种选择。由于脂肪瘤有再生的可能性且SLT可转变为恶性肿瘤，因此需要长期随访。
