Gautam Nikhil, Abhilasha Pallavi
Department of Psychiatry, Christian Medical College and Hospital, Ludhiana, IND.
Cureus. 2025 Jan 3;17(1):e76839. doi: 10.7759/cureus.76839. eCollection 2025 Jan.
Lithium, divalproex, and oxcarbazepine are commonly prescribed medications used for the management of bipolar disorder, but each of these drugs comes with its own gamut of adverse effects that make these agents unfavorable in certain medical conditions. Endoxifen, a protein kinase C inhibitor and selective estrogen receptor modulator, originally used in breast cancer treatment, has recently emerged as a potential therapeutic option for managing manic episodes in bipolar disorder. This case report highlights the use of endoxifen in the management of severe manic symptoms of bipolar disorder in a 65-year-old male patient with medical comorbidities arising from traditional mood stabilizer drugs and its potential as an alternative treatment over such drugs.
锂盐、丙戊酸镁和奥卡西平是常用于治疗双相情感障碍的处方药，但这些药物都有各自一系列的不良反应，这使得它们在某些医疗情况下并不适用。4-羟基他莫昔芬是一种蛋白激酶C抑制剂和选择性雌激素受体调节剂，最初用于乳腺癌治疗，最近已成为治疗双相情感障碍躁狂发作的一种潜在治疗选择。本病例报告强调了4-羟基他莫昔芬在一名65岁男性双相情感障碍患者严重躁狂症状管理中的应用，该患者因传统心境稳定剂药物出现了合并症，以及它作为此类药物替代治疗的潜力。
