Patro Shubhransu, Sharma Vibha, Choudhary Arushi, Varuneil Yallambhotla, Pathi Basanti Kumari, Pattnaik Sidharth S
General Medicine, Kalinga Institute of Medical Sciences, Bhubaneswar, IND.
Microbiology, Kalinga Institute of Medical Sciences, Bhubaneswar, IND.
Cureus. 2025 Jan 1;17(1):e76742. doi: 10.7759/cureus.76742. eCollection 2025 Jan.
Background Opportunistic pathogens such as and within the genus are significant causes of morbidity and mortality, especially in immunocompromised individuals. Despite their clinical importance, these infections are often underreported in resource-poor settings due to diagnostic challenges. This study investigates the prevalence, clinical profiles, and antibiotic resistance patterns seen in infections in a tertiary care hospital in India. Methods This retrospective study analyzed 56 hospitalized patients with infections diagnosed between June 2022 and June 2024. Positive cultures were identified using biochemical and morphological criteria. Demographic, clinical, and laboratory data, as well as antibiotic susceptibility profiles, were reviewed. Statistical analysis included descriptive measures and comparisons between and . Results The study included 56 patients, predominantly male (66.10%), with a mean age of 50.10 years. Comorbidities such as diabetes (39.30%) and hypertension (35.70%) were common. Blood cultures were the most frequent sample type, yielding positive results, with isolated in 67.60% of cases and in 32.40%. Patients with exhibited a stronger systemic inflammatory response, reflected by significantly elevated procalcitonin levels (p = 0.035) compared to . While C-reactive protein levels were also higher in , the difference was not statistically significant (p = 0.066). Both species demonstrated sensitivity to carbapenems and beta-lactam/beta-lactamase inhibitors, but notable resistance to aminoglycosides and cephalosporins was observed. showed high resistance to amikacin (41.20%) and cefepime (41.20%) while exhibited resistance to piperacillin/tazobactam (30.8%) and aztreonam (30.80%). Conclusion This study highlights distinct clinical and microbiological characteristics of and with distinct inflammatory markers and resistance patterns that underscore the need for precise diagnostic tools and tailored antibiotic therapy. Carbapenems and beta-lactam/beta-lactamase inhibitors remain effective treatment options, but emerging resistance necessitates effective antimicrobial stewardship for combating antimicrobial resistance and ensuring optimal patient outcomes. Further multicentric studies are essential to validate these findings and optimize management strategies for infections.
曲霉属等机会性病原体是发病和死亡的重要原因，尤其是在免疫功能低下的个体中。尽管它们具有临床重要性，但由于诊断方面的挑战，这些感染在资源匮乏地区往往报告不足。本研究调查了印度一家三级护理医院曲霉感染的患病率、临床特征和抗生素耐药模式。方法：这项回顾性研究分析了2022年6月至2024年6月期间确诊的56例住院曲霉感染患者。使用生化和形态学标准鉴定阳性培养物。回顾了人口统计学、临床和实验室数据以及抗生素敏感性谱。统计分析包括描述性指标以及曲霉属之间的比较。结果：该研究纳入了56例患者，以男性为主（66.10%），平均年龄为50.10岁。糖尿病（39.30%）和高血压（35.70%）等合并症很常见。血培养是最常获得阳性结果的样本类型，烟曲霉在67.60%的病例中分离得到，黄曲霉在32.40%的病例中分离得到。与黄曲霉相比，烟曲霉感染患者表现出更强的全身炎症反应，降钙素原水平显著升高（p = 0.035）。虽然C反应蛋白水平在烟曲霉感染患者中也较高，但差异无统计学意义（p = 0.066）。两种曲霉对碳青霉烯类和β-内酰胺/β-内酰胺酶抑制剂均敏感，但对氨基糖苷类和头孢菌素类有明显耐药性。烟曲霉对阿米卡星（41.20%）和头孢吡肟（41.20%）耐药性高，而黄曲霉对哌拉西林/他唑巴坦（30.8%）和氨曲南（30.80%）耐药。结论：本研究突出了烟曲霉和黄曲霉不同的临床和微生物学特征，以及不同的炎症标志物和耐药模式，强调了需要精确的诊断工具和量身定制的抗生素治疗。碳青霉烯类和β-内酰胺/β-内酰胺酶抑制剂仍然是有效的治疗选择，但新出现的耐药性需要有效的抗菌药物管理，以对抗抗菌药物耐药性并确保最佳患者预后。进一步的多中心研究对于验证这些发现并优化曲霉感染的管理策略至关重要。
