Pirahesh Kasra, Zarrinnia Ali, Nikniaz Leila, Nikniaz Zeinab
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Students` Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Prev Med Rep. 2025 Jan 9;50:102968. doi: 10.1016/j.pmedr.2025.102968. eCollection 2025 Feb.
Considering that both long and short sleep duration may have an association with nonalcoholic fatty liver disease (NAFLD), in this meta-analysis, we analyzed the dose-response association between sleep duration and NAFLD along with meta-analyses of the differences in mean sleep duration between NAFLD patients and healthy controls, and linear meta-analysis of the association between sleep duration and NAFLD.
PubMed (665 articles), Scopus (442 articles), and Web of Sciences (200 articles) were searched from inception until November 2023. Observational studies were included if they assess the association between sleep duration and NAFLD or compare the mean sleep duration between patients with NAFLD and healthy population. All studies done in humans without restriction on sex, age, and language were included. The methological quality of studies was assessed by Joanna Briggs Institute (JBI) tools. The meta-analysis was conducted using STATA.
Thirty-one studies that included 836,117 participants were included in this systematic review. The results indicated no significant differences between NAFLD patients and healthy controls regarding mean sleep duration [Mean difference: -7.08, 95 % CI: -20.10, 5.94]. The subgroup meta-analysis did not show any significant differences between groups. The long versus short sleep duration meta-analysis showed a significant association between sleep duration and NAFLD (OR: 0.8 [95 % CI, 0.74-0.91]). The results of the dose-response meta-analysis do not suggest a linear or nonlinear relationship between sleep duration and NAFLD (-value = 0.9).
The highest category of sleep duration was associated with a lower risk of NAFLD. However, no dose-response association was observed.
鉴于睡眠时间过长和过短都可能与非酒精性脂肪性肝病（NAFLD）相关，在本荟萃分析中，我们分析了睡眠时间与NAFLD之间的剂量反应关系，同时对NAFLD患者与健康对照者的平均睡眠时间差异进行了荟萃分析，以及对睡眠时间与NAFLD之间的关联进行了线性荟萃分析。
检索了从创刊至2023年11月的PubMed（665篇文章）、Scopus（442篇文章）和Web of Sciences（200篇文章）。纳入评估睡眠时间与NAFLD之间关联或比较NAFLD患者与健康人群平均睡眠时间的观察性研究。纳入所有在人类中进行的、不受性别、年龄和语言限制的研究。采用乔安娜·布里格斯研究所（JBI）工具评估研究的方法学质量。使用STATA进行荟萃分析。
本系统评价纳入了31项研究，共836,117名参与者。结果表明，NAFLD患者与健康对照者在平均睡眠时间方面无显著差异[平均差异：-7.08，95%置信区间：-20.10，5.94]。亚组荟萃分析未显示组间有任何显著差异。长睡眠时间与短睡眠时间的荟萃分析显示睡眠时间与NAFLD之间存在显著关联（比值比：0.8 [95%置信区间，0.74 - 0.91]）。剂量反应荟萃分析结果未表明睡眠时间与NAFLD之间存在线性或非线性关系（P值 = 0.9）。
睡眠时间最长的类别与较低的NAFLD风险相关。然而，未观察到剂量反应关系。
