Tafti Mahsa Fallah, Fayyaz Zeinab, Aghamollaei Hossein, Jadidi Khosrow, Faghihi Shahab
Stem Cell and Regenerative Medicine Group, National Institute of Genetic Engineering and Biotechnology, Tehran 14965/161, Iran.
Edison Biotechnology Institute, Ohio University, Athens, OH, 45701, USA.
Heliyon. 2025 Jan 10;11(2):e41881. doi: 10.1016/j.heliyon.2025.e41881. eCollection 2025 Jan 30.
Anterior eye disorders including dry eye syndrome, keratitis, chemical burns, and trauma have varying prevalence rates in the world. Classical dosage forms based-topical ophthalmic drugs are popular treatments for managing corneal diseases. However, current dosage forms of ocular drugs can be associated with major challenges such as the short retention time in the presence of ocular barriers. Developing alternative therapeutic methods is required to overcome drug bioavailability from ocular barriers. Nanocarriers are major platforms and promising candidates for the administration of ophthalmic drugs in an adjustable manner. This paper briefly introduces the advantages, disadvantages, and characteristics of delivery systems for the treatment of corneal diseases. Additionally, advanced technologies such as 3D printing are being considered to fabricate ocular drug carriers and determine drug dosages for personalized treatment. This comprehensive review is gathered through multiple databases such as Google Scholar, PubMed, and Web of Science. It explores information around "ocular drug delivery systems'', "nano-based drug delivery systems'', "engineered nanocarriers'', and "advanced technologies to fabricate personalized drug delivery systems''.
包括干眼症、角膜炎、化学灼伤和外伤在内的眼前部疾病在世界范围内的患病率各不相同。基于传统剂型的局部眼科药物是治疗角膜疾病的常用方法。然而，目前的眼部药物剂型可能面临重大挑战，例如在存在眼部屏障的情况下药物滞留时间短。需要开发替代治疗方法来克服眼部屏障对药物生物利用度的影响。纳米载体是主要平台，有望以可调节的方式用于眼科药物给药。本文简要介绍了用于治疗角膜疾病的递送系统的优缺点和特性。此外，正在考虑采用3D打印等先进技术来制造眼部药物载体并确定个性化治疗的药物剂量。这篇综述是通过谷歌学术、PubMed和科学网等多个数据库收集的。它探索了围绕“眼部药物递送系统”、“纳米药物递送系统”、“工程纳米载体”以及“制造个性化药物递送系统的先进技术”的信息。
