Din-Udom A, Sujarit S, Pholpramool C
J Reprod Fertil. 1985 Mar;73(2):405-10. doi: 10.1530/jrf.0.0730405.
Short-term effects of bilateral castration, cyproterone acetate and unilateral efferent duct ligation on intraluminal pressures and spontaneous contractions in different regions of the epididymis were studied in the rat. Ligation of the efferent ducts for 5 days did not alter pressures or spontaneous contractions in any region of the epididymis. However, bilateral castration produced time-dependent changes in pressures and contractions in different segments. In the caput, the amplitude, but not the basal pressure or the frequency, of spontaneous contractions increased by Day 1 after operation. In the corpus, increments in the basal pressure and the amplitude of contractions occurred by Day 5 whilst the frequency of contractions was not changed. Similar effects were observed in the cauda by 3 days after castration. Changes in all regions of the epididymis were also mimicked by cyproterone acetate treatment (10 mg/rat per day, s.c. for 21 days). In addition, this drug increased the amplitude of contractions in the cauda. The effect of castration was abolished by testosterone propionate (0.2 mg/kg per day, i.m. for 5 days). The results support the suggestion that an enhancement of sperm transport through the rat epididymis occurs shortly after castration. The results also suggest that, in normal rats, androgens suppress the contractility of the epididymal tubule to ensure an optimal rate of sperm transport.
在大鼠中研究了双侧去势、醋酸环丙孕酮和单侧输出小管结扎对附睾不同区域腔内压力和自发收缩的短期影响。输出小管结扎5天未改变附睾任何区域的压力或自发收缩。然而，双侧去势使不同节段的压力和收缩产生了时间依赖性变化。在附睾头，术后第1天自发收缩的幅度增加，但基础压力或频率未改变。在附睾体，基础压力和收缩幅度在第5天增加，而收缩频率未改变。去势后3天在附睾尾观察到类似效应。醋酸环丙孕酮治疗（10mg/大鼠/天，皮下注射21天）也模拟了附睾所有区域的变化。此外，该药物增加了附睾尾收缩的幅度。丙酸睾酮（0.2mg/kg/天，肌肉注射5天）消除了去势的影响。结果支持了去势后不久大鼠附睾精子运输增强的观点。结果还表明，在正常大鼠中，雄激素抑制附睾小管的收缩性以确保最佳的精子运输速率。
