Yoshioka T, Sugimoto T, Ukai T, Oshiro T
J Trauma. 1985 Apr;25(4):281-7. doi: 10.1097/00005373-198504000-00001.
Hemolysis does not necessarily result in acute renal failure in severely burned patients, but free serum hemoglobin may play some important role in the development of renal damage. This controlled study of the effects of haptoglobin administration in severely burned patients presenting with hemoglobinuria produced the following results: As long as free hemoglobin was present in the plasma, free serum haptoglobin remained undetectable. Free serum hemoglobin dropped rapidly after haptoglobin treatment, whereas the free serum hemoglobin levels in control patients remained unchanged for at least 12 hours. The time required for macroscopic hemoglobinuria to clear showed a statistically significant difference between the haptoglobin-treated patients and the control patients. Some patients among the haptoglobin-treated group had prolonged hemolysis and hemoglobinuria which might have cleared with additional doses of haptoglobin.
溶血并不一定会导致严重烧伤患者出现急性肾衰竭，但游离血清血红蛋白可能在肾损伤的发展过程中发挥一些重要作用。这项关于给予严重烧伤且出现血红蛋白尿患者触珠蛋白的对照研究产生了以下结果：只要血浆中存在游离血红蛋白，就无法检测到游离血清触珠蛋白。触珠蛋白治疗后游离血清血红蛋白迅速下降，而对照组患者的游离血清血红蛋白水平至少12小时保持不变。肉眼可见的血红蛋白尿清除所需时间在触珠蛋白治疗组患者和对照组患者之间存在统计学上的显著差异。触珠蛋白治疗组中的一些患者溶血和血红蛋白尿持续时间延长，额外剂量的触珠蛋白可能会使其清除。
