Singh Widhilika, Kushwaha Poonam, Kushwaha Shom Prakash
Department of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India.
J Am Nutr Assoc. 2025 Aug;44(6):508-520. doi: 10.1080/27697061.2025.2460539. Epub 2025 Feb 3.
Menatetrenone (MK-4), a potent form of vitamin K2, has gained significant attention for its diverse therapeutic potential, particularly in bone health, cardiovascular protection, and metabolic disorders. This manuscript explores the origins and chemical structure of menatetrenone, highlighting its synthesis from dietary sources and its enzymatic conversion in the body. The review examines the extensive therapeutic applications of MK-4, focusing on its role in treating osteoporosis, diabetes, and cardiovascular diseases, along with emerging evidence of its anticancer and neuroprotective effects. Furthermore, the manuscript discusses innovative delivery systems, such as nanostructured lipid carriers and other advanced formulations, designed to enhance the bioavailability and therapeutic efficacy of menatetrenone. By addressing the challenges associated with its pharmacokinetics and exploring novel drug delivery strategies, this review provides a comprehensive overview of menatetrenone's therapeutic promise and outlines future directions for its clinical use.
甲萘醌四烯（MK-4）是维生素K2的一种有效形式，因其具有多种治疗潜力而备受关注，尤其是在骨骼健康、心血管保护和代谢紊乱方面。本文探讨了甲萘醌四烯的起源和化学结构，重点介绍了其从饮食来源的合成以及在体内的酶促转化。该综述研究了MK-4广泛的治疗应用，着重关注其在治疗骨质疏松症、糖尿病和心血管疾病中的作用，以及其抗癌和神经保护作用的新证据。此外，本文还讨论了创新的给药系统，如纳米结构脂质载体和其他先进制剂，旨在提高甲萘醌四烯的生物利用度和治疗效果。通过应对与其药代动力学相关的挑战并探索新型药物递送策略，本综述全面概述了甲萘醌四烯的治疗前景，并概述了其临床应用的未来方向。
