茶碱在马体内的药代动力学研究。
Pharmacokinetic studies of theophylline in horses.
作者信息
Ingvast-Larsson C, Paalzow G, Paalzow L, Ottosson T, Lindholm A, Appelgren L E
出版信息
J Vet Pharmacol Ther. 1985 Mar;8(1):76-81. doi: 10.1111/j.1365-2885.1985.tb00927.x.
The pharmacokinetics of theophylline were determined in Standardbred trotters after single intravenous and oral administration. A bi-exponential equation was fitted to the intravenous data and a tri-exponential equation to the oral data. The biological half-life of theophylline was found to be 14.8 h, the volume of distribution 1.02 l/kg and the total plasma clearance 0.86 ml/kg/min. The oral absorption of the drug was complete (bioavailability 108%) and rapid (absorption half-life 0.4 h).
在标准赛马快步马单次静脉注射和口服给药后，测定了茶碱的药代动力学。用双指数方程拟合静脉注射数据，用三指数方程拟合口服数据。发现茶碱的生物半衰期为14.8小时，分布容积为1.02升/千克，总血浆清除率为0.86毫升/千克/分钟。该药物的口服吸收完全（生物利用度108%）且迅速（吸收半衰期0.4小时）。
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