Chen Jiaqi, Yuan Mengzhu, Wang Jianping
Department of Endocrinology and Metabolic Disease, The Second Affiliated Hospital, University of South China, Hengyang, Hunan, 421001, China.
Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.
Mol Biol Rep. 2025 Feb 3;52(1):185. doi: 10.1007/s11033-024-10193-5.
SLC7A11, often called xCT, belongs to the SLC family of transporters, which mediates the cellular influx of cystine and the efflux of glutamate. These transport processes are crucial for synthesizing GSH, enhancing the cell's ability to mitigate oxidative stress (OS). Emerging studies highlight the pivotal role of OS in triggering and exacerbating various metabolic and endocrine disorders, underlining the critical importance of regulating SLC7A11 expression levels. This study reviews the diverse roles of SLC7A11 in endocrine and metabolic diseases, examining its relationship with the metabolism of three key nutrients: proteins and amino acids, carbohydrates, and lipids. Additionally, the involvement of SLC7A11 in the onset and development of various common endocrine and metabolic disorders is analyzed. Additionally, it provides an overview of the current clinical and experimental use of SLC7A11 inhibitors and agonists. This review aims to offer insightful perspectives into the involvement of SLC7A11 in endocrine and metabolic pathologies and to foster the development of innovative therapeutic strategies that target SLC7A11.
溶质载体家族7成员11（SLC7A11），通常称为xCT，属于转运蛋白的SLC家族，它介导细胞对胱氨酸的摄取和谷氨酸的外流。这些转运过程对于合成谷胱甘肽（GSH）、增强细胞减轻氧化应激（OS）的能力至关重要。新兴研究强调了氧化应激在引发和加剧各种代谢和内分泌疾病中的关键作用，凸显了调节SLC7A11表达水平的至关重要性。本研究综述了SLC7A11在内分泌和代谢疾病中的多种作用，探讨了其与三种关键营养素（蛋白质和氨基酸、碳水化合物及脂质）代谢的关系。此外，还分析了SLC7A11在各种常见内分泌和代谢疾病的发生和发展中的作用。此外，还概述了SLC7A11抑制剂和激动剂目前在临床和实验中的应用情况。本综述旨在深入探讨SLC7A11在内分泌和代谢病理学中的作用，并推动针对SLC7A11的创新治疗策略的发展。
