Besnier Florent, Dupuy Emma Gabrielle, Gagnon Christine, Vincent Thomas, Vrinceanu Tudor, Blanchette Caroll-Ann, Iglesies-Grau Josep, Saillant Kathia, Chabot-Blanchet Malorie, Belleville Sylvie, Juneau Martin, Vitali Paolo, Gayda Mathieu, Nigam Anil, Bherer Louis
Research Center and Centre ÉPIC, Montreal Heart Institute, Université de Montréal, Montréal, Québec, H1T 1N6, Canada.
Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, Québec, H3C 3J7, Canada.
Geroscience. 2025 Feb 3. doi: 10.1007/s11357-025-01530-y.
This randomized controlled trial compared the effects of home-based exercise, with or without cognitive training, on cognition and physical function in individuals aged 50 years and older with stable CVD during the COVID-19 pandemic. 122 patients (67.3 ± 7.9 years, 71% men) with stable CVD (77% coronary heart disease) were randomly assigned (1:1) to (1) Home-based physical exercise alone, or (2) Home-based physical exercise combined with cognitive training. Cognition (executive functions (primary outcome), processing speed, episodic memory, and working memory) and physical functions were assessed remotely at baseline, 3 months, and 6 months. Adjusted mean changes from baseline to 3 months and 6 months for executive functions, episodic memory, working memory, sit-to-stand test, gait speed, and timed up-and-go test were significant in the overall sample (p < 0.05). Furthermore, executive functions, episodic memory, sit-to-stand test, and timed up-and-go performances were significantly improved at 6 months in both groups when analyzed separately although no group differences were observed. Mean exercise dose differed significantly between the 2 groups: 1413 vs 953 METs.min week respectively for the exercise and combined group (p < 0.01). Mean cognitive training duration was 25.6 ± 16.6 min.week for the combined intervention group. Results remained unchanged after accounting for the exercise dose. In adults affected by CVD, a remote combined intervention integrating sequential cognitive and exercise training yields comparable enhancements in executive function, episodic memory, and physical performances compared to exercise training alone. ClinicalTrials.gov: NCT04661189.
这项随机对照试验比较了在2019年冠状病毒病大流行期间，居家锻炼（无论有无认知训练）对50岁及以上患有稳定心血管疾病（CVD）个体的认知和身体功能的影响。122例患有稳定CVD（77%为冠心病）的患者（67.3±7.9岁，71%为男性）被随机分配（1:1）至（1）仅居家体育锻炼组，或（2）居家体育锻炼与认知训练联合组。在基线、3个月和6个月时对认知（执行功能（主要结局）、处理速度、情景记忆和工作记忆）和身体功能进行远程评估。在总体样本中，从基线到3个月和6个月时，执行功能、情景记忆、工作记忆、坐立试验、步速和计时起立行走试验的调整后平均变化具有显著性（p<0.05）。此外，单独分析时，两组在6个月时执行功能、情景记忆、坐立试验和计时起立行走表现均有显著改善，尽管未观察到组间差异。两组的平均运动剂量差异显著：运动组和联合组分别为1413 vs 953 METs·min/周（p<0.01）。联合干预组的平均认知训练时长为25.6±16.6 min/周。在考虑运动剂量后结果保持不变。在受CVD影响的成年人中，与单独的运动训练相比，整合了序贯认知和运动训练的远程联合干预在执行功能、情景记忆和身体表现方面产生了相当的改善。ClinicalTrials.gov：NCT04661189。
