Sharif Salman, Afsar Afifa, Zileli Mehmet, Vaishya Sandeep, Gokaslan Ziya
Liaquat National Hospital & Medical College, Karachi, Pakistan.
Faculty of Medicine, Sanko University, Gaziantep, Turkey.
Neurosurg Rev. 2025 Feb 3;48(1):160. doi: 10.1007/s10143-025-03298-3.
This review aimed to formulate the most current, evidence-based recommendations for the prediction of outcome, life expectancy, and quality of life in patients with metastatic vertebral tumors. A systematic literature search on PubMed and Google Scholar from 2012-2022 was done, using the keywords "metastatic vertebral tumors + outcome prediction + prognoses," "quality of life + spine metastases," and "spine metastases + life expectancy." Our PubMed search yielded 402 articles for outcome prediction, whereas 40 articles were identified for life expectancy in spine metastases. These were carefully screened by the co-authors, resulting in 61 and 11 final articles analyzed for this study. Our PubMed search for quality of life yielded 137 articles, of which 63 were carefully analyzed for this study. This up-to-date information was reviewed at two separate Spine Committee meetings of the World Federation of Neurosurgical Societies (WFNS). Two rounds of the Delphi method were used to vote and arrive at a positive or negative consensus. The WFNS Spine Committee finalized seven recommendation guidelines on the prediction of outcome, life expectancy, and quality of life in metastatic vertebral tumors. Irrespective of the primary tumor, surgical decompression in appropriately selected patients potentially improves the quality of life. Pre-operative ambulatory status, overall performance, and age are independent predictors of outcome and overall survival. Prognostic scoring systems have evolved to principle-based algorithms, amongst which NOMS is the most widely used.The best tools to measure the quality of life are EUQOL5-D and SOSGOQ in patients with metastatic spine disease.
本综述旨在制定关于转移性脊柱肿瘤患者预后、预期寿命和生活质量预测的最新、基于证据的建议。我们在PubMed和谷歌学术上进行了系统的文献检索，检索时间为2012年至2022年，关键词为“转移性脊柱肿瘤+预后预测+预后”、“生活质量+脊柱转移瘤”和“脊柱转移瘤+预期寿命”。我们在PubMed上检索到402篇关于预后预测的文章，而关于脊柱转移瘤预期寿命的文章有40篇。共同作者对这些文章进行了仔细筛选，最终确定61篇和11篇文章用于本研究分析。我们在PubMed上检索到137篇关于生活质量的文章，其中63篇被仔细分析用于本研究。这些最新信息在世界神经外科协会联合会（WFNS）的两次独立脊柱委员会会议上进行了审查。采用两轮德尔菲法进行投票，以达成肯定或否定的共识。WFNS脊柱委员会最终确定了七条关于转移性脊柱肿瘤预后、预期寿命和生活质量预测的推荐指南。无论原发肿瘤如何，在适当选择的患者中进行手术减压可能会改善生活质量。术前的行走状态、总体表现和年龄是预后和总生存的独立预测因素。预后评分系统已发展为基于原则的算法，其中NOMS是使用最广泛的。在转移性脊柱疾病患者中，衡量生活质量的最佳工具是EUQOL5-D和SOSGOQ。
