Johnston J M, Becker S F, McFarland L M
JAMA. 1985 May 17;253(19):2850-3. doi: 10.1001/jama.253.19.2850.
To identify risk factors for Vibrio vulnificus infections, we performed a regional case-control study of 19 patients identified by isolates received at a state reference laboratory. Interviews with patients or surviving relatives and with three controls for each patient were compared in a matched analysis. Patients with V vulnificus wound infection were more likely than controls to have sustained a puncture wound while handling fresh seafood or to have been exposed to salt water. More patients with primary septicemia than controls had eaten raw oysters before the onset of illness. Other risk factors for septicemia included underlying liver disease, hematopoietic disorders, chronic renal insufficiency, use of immunosuppressive agents, and heavy alcohol consumption. Although V vulnificus infection is unusual, with a regional incidence of 0.8 per 100,000 population in this study, septicemia in the immunosuppressed patient is a devastating illness that can be prevented by not eating raw seafood.
为确定创伤弧菌感染的风险因素，我们开展了一项区域性病例对照研究，研究对象为州参考实验室收到的分离菌株鉴定出的19名患者。在配对分析中，对比了对患者或幸存亲属以及每名患者的三名对照进行的访谈。创伤弧菌伤口感染患者比对照更有可能在处理新鲜海鲜时受到刺伤或接触过盐水。原发性败血症患者中在发病前食用生牡蛎的人数比对照更多。败血症的其他风险因素包括潜在的肝脏疾病、造血系统疾病、慢性肾功能不全、使用免疫抑制剂以及大量饮酒。虽然创伤弧菌感染并不常见，在本研究中区域发病率为每10万人0.8例，但免疫功能低下患者发生的败血症是一种可通过不食用生海鲜来预防的严重疾病。
