Della Corte Luigi, Palumbo Mario, Ascione Mario, D'Angelo Giuseppe, La Verde Marco, Ferrari Federico, Morra Ilaria, Bifulco Giuseppe
Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples "Federico II", Naples, Italy.
Department of Public Health, School of Medicine, University of Naples "Federico II", Naples, Italy.
Gynecol Obstet Invest. 2025 Feb 3:1-10. doi: 10.1159/000543869.
BRCA 1 and 2 mutation carriers are invited to follow intensive clinical and instrumental surveillance programs or are offered prophylactic ovarian surgery. These recommendations impact many aspects of their lives. The primary objective of this study was to assess the overall quality of life (HRQoL) before and after prophylactic bilateral salpingo-oophorectomy (BSO). Secondary objectives were investigating sexual health (SH) and fatigue severity state.
This was a single-center retrospective observational study.
Women who underwent surgical treatment of bilateral salpingo-oophorectomy between 2018 and 2024 at "DAI Materno Infantile" of Azienda Ospedaliera Universitaria "Federico II" of Naples were included.
These patients were tracked down to undergo specific questionnaires, such as "Global Health Status (GHS) and Quality of Life Scale (QOL) (EORTC QLQ-C30)," "EORTC Sexual Health Questionnaire (QLQ-SH22)," and "Fatigue Severity Scale (FSS)," to evaluate their psychological, sexual, and general physical condition impact before the surgery, 3 and 6 months later.
The overall mean QoL score was 88.3 ± 29.8 (mean ± standard deviation), and this score worsened when the surgery was performed at 3 months (p < 0.0001) with a score of 51.7 ± 30.7 and a mean difference (MD) of 36.6 points; instead, at 6 months, the overall mean QoL score was 73.1 ± 24.3 with an MD of 21.4 points. FSS reported a score of 2.7 ± 1.15 vs 4.2 ± 1.59 (p < 0.0001) vs 3.5 ± 1.43 (p < 0.0001), respectively, before and 3-6 months after surgery. EORTC QLQ-SH22 before and after treatment showed statistically significant changes in sexual satisfaction (p < 0.0001).
BSO may impact the quality of life regardless of the hormonal status of patients related to age or menopause, about both the functional evaluation and the psychological and emotional assessment report. The physical change related to the surgical procedure is associated with a mental shift that affects both the physical and sexual energy of our patients in the first 3 months postoperatively, with a slight improvement of these data at 6 months.
BRCA 1和2基因突变携带者被邀请接受强化临床和仪器监测项目，或接受预防性卵巢手术。这些建议会影响她们生活的许多方面。本研究的主要目的是评估预防性双侧输卵管卵巢切除术（BSO）前后的总体生活质量（HRQoL）。次要目的是调查性健康（SH）和疲劳严重程度。
这是一项单中心回顾性观察研究。
纳入了2018年至2024年在那不勒斯“费德里科二世”大学医院“妇幼医院”接受双侧输卵管卵巢切除术手术治疗的女性。
追踪这些患者，让她们接受特定问卷，如“全球健康状况（GHS）和生活质量量表（QOL）（欧洲癌症研究与治疗组织QLQ-C30）”、“欧洲癌症研究与治疗组织性健康问卷（QLQ-SH22）”和“疲劳严重程度量表（FSS）”，以评估手术前、术后3个月和6个月对她们心理、性和一般身体状况的影响。
总体平均生活质量得分是88.3±29.8（平均值±标准差），当在3个月时进行手术时该得分恶化（p<0.0001），得分为51.7±30.7，平均差异（MD）为36.6分；相反，在6个月时，总体平均生活质量得分为73.1±24.3，平均差异为21.4分。FSS报告术前、术后3个月和6个月的得分分别为2.7±1.15、4.2±1.59（p<0.0001）、3.5±1.43（p<0.0001）。治疗前后欧洲癌症研究与治疗组织QLQ-SH22在性满意度方面显示出统计学上的显著变化（p<0.0001）。
无论患者与年龄或绝经相关的激素状态如何，BSO都可能影响生活质量，无论是功能评估还是心理和情绪评估报告。与手术相关的身体变化与一种心理转变相关，这种转变在术后前3个月影响患者的身体和性活力，在6个月时这些数据略有改善。
