Takase Y, Kikuchi M, Ozaki A, Shibuya S, Iwasaki Y
Jpn J Surg. 1985 Jan;15(1):30-5. doi: 10.1007/BF02469854.
Injection sclerotherapy is one of the most effective treatments for esophageal varices. To investigate the fate of esophageal varices embolized with a sclerosant (ethanolamine oleate), we have examined at autopsy the esophageal wall of 14 patients with esophageal varices. When the sclerosant was injected into the varices, at first thrombi formed. After two weeks, granulation tissue appeared and the thrombi were gradually replaced. The granulation tissues were organized slowly after 3 months and in the organized granulation tissue, microscopic recanalization of vessels were seen in 8 out of 9 cases. There was no recurrence of the original varices and de novo varices occurred in one patient. These observations indicate that the varices embolized with ethanolamine oleate become organized in three months after the treatment, and accordingly the esophageal varices are cured. It became also clear that recurrence of the original varices did not occur after the organization.
注射硬化疗法是治疗食管静脉曲张最有效的方法之一。为了研究用硬化剂（油酸乙醇胺）栓塞的食管静脉曲张的转归，我们对14例食管静脉曲张患者的食管壁进行了尸检。当将硬化剂注入静脉曲张时，起初会形成血栓。两周后，出现肉芽组织，血栓逐渐被取代。3个月后肉芽组织缓慢机化，在9例机化的肉芽组织中，有8例可见血管的微观再通。原静脉曲张无复发，1例患者出现新生静脉曲张。这些观察结果表明，用油酸乙醇胺栓塞的静脉曲张在治疗后三个月内会机化，因此食管静脉曲张得以治愈。同样清楚的是，机化后原静脉曲张不会复发。
