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[心肌梗死和不稳定型心绞痛患者在一年观察期内血浆脂蛋白和载脂蛋白谱指标的变化]

[Changes in the indices of plasma lipoprotein and apolipoprotein spectra in patients with myocardial infarct and unstable stenocardia over the course of a year's observation].

作者信息

Noeva E A, Perova N V, Gerasimova E N, Metel'skaia V A, Chernysheva N P

出版信息

Kardiologiia. 1985 Feb;25(2):46-52.

PMID:3990079
Abstract

Over the period of one year the authors examined the changes in the parameters of the plasma spectrum of lipoproteins and apolipoproteins in 46 patients with acute macrofocal myocardial infarction and 35 patients with labile angina. In six cases variations in these parameters were studied in the course of unstable angina and in the post-infarction period. It was established that myocardial infarction induced specific alterations in the plasma lipoprotein system not only in the immediate post-infarction period but also at more long-term periods. Myocardial infarction causes deep and prolonged disorders in the apolipoprotein system which may contribute to the progression of atherosclerotic damage to the coronary arteries.

摘要

在一年的时间里,作者对46例急性大面积心肌梗死患者和35例不稳定型心绞痛患者的血浆脂蛋白和载脂蛋白谱参数变化进行了研究。在6例患者中,对这些参数在不稳定型心绞痛发作过程及心肌梗死后时期的变化进行了研究。结果表明,心肌梗死不仅在梗死急性期,而且在更长时期内,都会引起血浆脂蛋白系统的特异性改变。心肌梗死会导致载脂蛋白系统出现深刻且持久的紊乱,这可能会促使冠状动脉粥样硬化损伤的进展。

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