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出血的动物模型、参数及止血方法的发展

Animal models of hemorrhage, parameters, and development of hemostatic methods.

作者信息

Darya Gholamhossien, Mohammadi Hamid, Dehghan Zeinab, Nakhaei Alireza, Derakhshanfar Amin

机构信息

Department of Comparative Biomedical Sciences, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.

Department of Pediatric, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

出版信息

Lab Anim Res. 2025 Feb 3;41(1):5. doi: 10.1186/s42826-025-00239-5.

Abstract

Hemorrhage is a prevalent side effect of various injuries and can be life-threatening in certain instances. It is categorized into compressible and non-compressible types, each necessitating distinct modeling, laboratory assessments, and hemostatic approaches. This study utilized the keywords Hemorrhage, Bleeding, Animal Modeling, and Hemostat in reputable databases. The findings indicate that femoral artery hemorrhage and hepatic parenchymal hemorrhage are the predominant modeling techniques for compressible and non-compressible bleeding, respectively. Furthermore, it is noted that animal models of compressible hemorrhages are primarily situated in superficial body areas to investigate dressing or additive hemostats, while non-compressible hemorrhage models, typically located in visceral organs, are employed to examine adhesive or surgical instrument-based hemostats.

摘要

出血是各种损伤常见的副作用,在某些情况下可能危及生命。它分为可压迫性和不可压迫性两类,每一类都需要不同的建模、实验室评估和止血方法。本研究在著名数据库中使用了“出血”“流血”“动物模型”和“止血剂”等关键词。研究结果表明,股动脉出血和肝实质出血分别是可压迫性和不可压迫性出血的主要建模技术。此外,值得注意的是,可压迫性出血的动物模型主要位于身体浅表部位,以研究敷料或添加剂止血剂,而不可压迫性出血模型通常位于内脏器官,用于研究基于粘合剂或手术器械的止血剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedc/11789289/76dfd9826f6e/42826_2025_239_Fig1_HTML.jpg

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