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一名服用甲状腺激素替代药物的女性中依托孕烯植入剂失效:病例报告

Etonogestrel implant failure in a woman taking thyroid hormone replacement: A case report.

作者信息

Moylan Alice, Brown Jewel, Chen Melissa J, Creinin Mitchell D

机构信息

University of California, Davis School of Medicine, 4610 X St., Sacramento, CA 95817, USA.

Department of Obstetrics and Gynecology, University of California, Davis Health, 4860 Y Street, Suite 2500, Sacramento, CA 95817, USA.

出版信息

Case Rep Womens Health. 2025 Jan 17;45:e00687. doi: 10.1016/j.crwh.2025.e00687. eCollection 2025 Mar.

Abstract

The etonogestrel implant is known to have high contraceptive efficacy for up to 5 years. This case report describes etonogestrel implant failure during year 4 of use in a patient with a normal body mass index. The patient was receiving thyroid hormone replacement after a thyroidectomy and was found to have iatrogenic thyrotoxicosis in the months preceding pregnancy. Further study of the effects of thyroid hormone on etonogestrel metabolism are indicated.

摘要

已知依托孕烯植入剂在长达5年的时间内具有较高的避孕效果。本病例报告描述了一名体重指数正常的患者在使用依托孕烯植入剂第4年时避孕失败的情况。该患者在甲状腺切除术后接受甲状腺激素替代治疗,在怀孕前几个月被发现患有医源性甲状腺毒症。有必要进一步研究甲状腺激素对依托孕烯代谢的影响。

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本文引用的文献

1
The impact of thyroid diseases starting from birth on reproductive function.从出生开始的甲状腺疾病对生殖功能的影响。
Hormones (Athens). 2019 Dec;18(4):365-381. doi: 10.1007/s42000-019-00156-y. Epub 2019 Nov 16.
7
Effect of thyroid hormone on the activity of CYP3A enzyme in humans.甲状腺激素对人体 CYP3A 酶活性的影响。
J Clin Pharmacol. 2010 Jan;50(1):88-93. doi: 10.1177/0091270009344336. Epub 2009 Oct 6.

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