Li Weiming, Xu Fenglian, Chen Feng, Cao Lei, Bao Xiaohang
Department of Anesthesiology, second Affiliated Hospital of Army Medical University, Chongqing, 400037, People's Republic of China.
Gynaecology and Obstetrics, second Affiliated Hospital of Army Medical University, Chongqing, 400037, People's Republic of China.
J Pain Res. 2025 Jan 30;18:511-522. doi: 10.2147/JPR.S503937. eCollection 2025.
To explore the effect of genicular nerve block (GNB) on pain in lesions of the knee joint. Computerized searches of randomized controlled trials were conducted in PubMed, EMbase, Cochrane Library, and Web of Science, with a search time frame until January 2024. Methodological and experimental quality was assessed using the risk of bias assessment tool recommended by the Cochrane Handbook. A meta-analysis was conducted of the pain score (as the primary outcome measure) using Review Manager 5.4 and Stata 17. Thirteen studies involving a total of 731 patients were ultimately included. In the comparison of GNB and non-GNB, the analysis results of analgesic effects at all visits showed [SMD=-0.51, 95% CI (-0.89, -0.14)]. Analysis of analgesic effects at a visit at 1 month showed [SMD=-0.79, 95% CI (-1.55, -0.02)]. Subgroup analysis for the control group showed [SMD=-4.07,9 5% CI (-4.10, -1.84)]. Currently, available evidence suggests that GNB may be an effective analgesic therapy and superior to other regimens in the treatment of lesions of the knee joint.
探讨膝神经阻滞（GNB）对膝关节病变疼痛的影响。在PubMed、EMbase、Cochrane图书馆和Web of Science中对随机对照试验进行计算机检索，检索时间范围至2024年1月。使用Cochrane手册推荐的偏倚风险评估工具评估方法学和实验质量。使用Review Manager 5.4和Stata 17对疼痛评分（作为主要结局指标）进行荟萃分析。最终纳入13项研究，共731例患者。在GNB与非GNB的比较中，各访视时镇痛效果的分析结果显示[标准化均数差（SMD）=-0.51，95%置信区间（CI）（-0.89，-0.14）]。1个月访视时镇痛效果的分析显示[SMD=-0.79，95%CI（-1.55，-0.02）]。对照组的亚组分析显示[SMD=-4.07，95%CI（-4.10，-1.84）]。目前，现有证据表明GNB可能是一种有效的镇痛疗法，在治疗膝关节病变方面优于其他方案。
