Zhang Dan-Qi, Yang Xu, Niu Han-Bin, Sun Xu-Chen, Cao Dan-Na, Li Ang, Yue Jin-Huan, Li Xiao-Ling, Zhang Qin-Hong
Department of Anesthesiology and Surgery, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, 150040, China.
Division of CT and MRI, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, 150040, China.
Curr Alzheimer Res. 2024;21(9):649-666. doi: 10.2174/0115672050351995241223065923.
This study analyzed the current status, hotspots, and development trends of tau protein research in Alzheimer's disease (AD) and to provide a reference for future research in this field. CiteSpace software was used to scientifically measure and visualize the relevant articles in the field of tau protein in AD brain from the Web of Science Core Collection database from 1991 to 2022.
A total of 568 articles were included, with an exponential growth in the number of articles published from 1991 to 2022, with an average of 17.8 articles per year. The United States is the most productive country in this field, accounting for 46.83% of the total literature. The New York State Institute for Basic Research is the most productive organization, followed by MRC Laboratory Molecular Biology in the UK. The most influential are Kings College London, University of California, San Francisco, and others. Iqbal K is the most productive author.
The most productive journal is the Journal of Biological Chemistry, and the journal with the highest impact factor is Acta Neuropathologica. The journal with the highest cumulative impact factor is Nature. The research hotspots mainly focus on the formation and degradation mechanisms of tau protein paired helical filaments and abnormal phosphorylation, AD neurofibrillary tangles and degenerative changes, and model research, mainly involving tau protein abnormal phosphorylation, phosphorylation sites, dephosphorylation, aggregate helical filaments, neurofibrillary tangles mouse models.
The research frontier trends mainly focus on the study of pathological changes in tau protein, intervention mechanisms, and the development and practice of clinical therapeutic drugs.
本研究分析了阿尔茨海默病（AD）中tau蛋白研究的现状、热点及发展趋势，为该领域未来研究提供参考。使用CiteSpace软件对1991年至2022年Web of Science核心合集数据库中AD脑内tau蛋白领域的相关文章进行科学计量和可视化分析。
共纳入568篇文章，1991年至2022年发表文章数量呈指数增长，年均17.8篇。美国是该领域发文量最多的国家，占文献总量的46.83%。纽约州基础研究所以发文量最多，其次是英国的医学研究委员会分子生物学实验室。最具影响力的是伦敦国王学院、加利福尼亚大学旧金山分校等。伊克巴尔·K是发文量最多的作者。
发文量最多的期刊是《生物化学杂志》，影响因子最高的期刊是《神经病理学学报》。累积影响因子最高的期刊是《自然》。研究热点主要集中在tau蛋白双螺旋丝的形成与降解机制及异常磷酸化、AD神经原纤维缠结与退行性变、模型研究，主要涉及tau蛋白异常磷酸化、磷酸化位点、去磷酸化、聚集双螺旋丝、神经原纤维缠结小鼠模型。
研究前沿趋势主要集中在tau蛋白病理变化的研究、干预机制以及临床治疗药物的研发与实践。
