Coton Sonia, Welburn Stephen, Williams Rachael, Campbell Jennifer
Clinical Practice Research Datalink (CPRD) Medicines and Healthcare Products Regulatory Agency, London, UK.
Pharmacoepidemiol Drug Saf. 2025 Feb;34(2):e70091. doi: 10.1002/pds.70091.
Maternal exposures before, during and after pregnancy can affect the infant. It is therefore important that researchers study mothers and their children. The CPRD GOLD Mother-Baby Link (MBL) algorithm was applied to the CPRD Aurum database, to extend the useful tool. Here, we present the algorithm and data resource profiles of the CPRD MBLs.
Records of female patients registered with a CPRD practice between the 1st January 1987 and the 1st June 2023 were searched for evidence of delivery. Infants born and registered between 1st January 1987 and 1st June 2023 were matched to mothers on practice and household indicators. The resulting MBLs were characterised.
The CPRD MBL algorithm was applied to the CPRD databases resulting in nearly four-million mother-baby pairs: 2.4-million in CPRD Aurum. Mothers in the CPRD GOLD and CPRD Aurum MBL's were similar in terms of age; mean age 29.6 years (SD = 5.7) vs. 30.2 years (SD = 5.7), and length of GP registration; mean = 14.4 years (SD = 10.9) vs. mean = 13.7 (SD = 10.9). The median number of matches was slightly higher in the CPRD GOLD MBL; 2 (IQR = 1, 2) vs. 1 (IQR = 1, 2). The number of matches in both databases peaked in 2008-2011, followed by a steady decline to 2023.
The CPRD MBL's offer a valuable tool for researchers to study the mother-infant relationship. Extending the CPRD MBL algorithm to CPRD Aurum has increased the capacity for researchers to investigate rarer exposures and outcomes.
孕期前、孕期中和产后母亲接触的物质会影响婴儿。因此，研究人员对母亲及其子女进行研究很重要。CPRD GOLD母婴关联（MBL）算法被应用于CPRD Aurum数据库，以扩展这一有用工具。在此，我们展示CPRD MBL的算法和数据资源概况。
检索1987年1月1日至2023年6月1日期间在CPRD医疗机构注册的女性患者记录，以寻找分娩证据。1987年1月1日至2023年6月1日期间出生并注册的婴儿根据医疗机构和家庭指标与母亲进行匹配。对所得的MBL进行特征描述。
CPRD MBL算法应用于CPRD数据库，产生了近400万对母婴：CPRD Aurum中有240万对。CPRD GOLD和CPRD Aurum MBL中的母亲在年龄方面相似；平均年龄分别为29.6岁（标准差=5.7）和30.2岁（标准差=5.7），全科医生注册时长也相似；平均分别为14.4年（标准差=10.9）和13.7年（标准差=10.9）。CPRD GOLD MBL中的匹配中位数略高；为2（四分位间距=1,2），而另一个为1（四分位间距=1,2）。两个数据库中的匹配数量在2008 - 2011年达到峰值，随后稳步下降至2023年。
CPRD MBL为研究人员研究母婴关系提供了一个有价值的工具。将CPRD MBL算法扩展到CPRD Aurum增加了研究人员调查罕见接触物质和结局的能力。
