用于靶向光热化疗的缺氧响应性胆红素超分子纳米前药
Hypoxia-responsive bilirubin supramolecular nanoprodrugs for targeted photothermal-chemotherapy.
作者信息
Xie Yu, Zheng Liangshun, Chen Tingting, Ding Yue
机构信息
School of Chemistry and Chemical Engineering, Nantong University, Nantong, 226019, P. R. China.
出版信息
Chem Commun (Camb). 2025 Feb 20;61(17):3512-3515. doi: 10.1039/d4cc06433j.
PMID:39903085
Abstract
A bilirubin supramolecular nanoprodrug (SCBR/TPZ) with enhanced cellular uptake towards the HepG2 cell line was constructed based on host-guest recognition, which provided an innovative strategy to design a hypoxia-responsive BR supramolecular nanoprodrug for lactose-targeted photothermal-chemotherapy (PTT-CT) with a synergistic effect towards HepG2.
摘要
基于主客体识别构建了一种对HepG2细胞系具有增强细胞摄取能力的胆红素超分子纳米前药（SCBR/TPZ），这为设计一种用于乳糖靶向光热化疗（PTT-CT）且对HepG2具有协同效应的缺氧响应性BR超分子纳米前药提供了一种创新策略。
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