Gaenzle Maximilian, Feisthammel Juergen, Pirlich Markus, Dietz Andreas, Stoehr Matthaeus
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Leipzig, Liebigstrasse 12, Haus 1, 04103, Leipzig, Germany.
Department of Oncology, Gastroenterology, Hepatology and Pneumology, University Hospital of Leipzig, Leipzig, Germany.
Eur Arch Otorhinolaryngol. 2025 Jun;282(6):3349-3355. doi: 10.1007/s00405-025-09227-w. Epub 2025 Feb 4.
Patients with recurrent head and neck carcinoma are considered for salvage surgery if resectability with clear margins is achievable. However, postoperative complications such as wound healing disorders and pharyngocutaneous fistulas remain significant challenges. While various reconstructive surgical techniques exist, supportive vacuum therapy-both external and endoluminal-has been explored as an alternative treatment modality.
We present a case report of a 60-year-old male patient with recurrent laryngeal cancer who underwent salvage laryngopharyngectomy following multiple previous surgical procedures and definitive radiochemotherapy. Due to persistent pharyngocutaneous fistula formation despite multiple reconstructions using pectoralis major flaps, an anterolateral thigh flap, and a fasciocutaneous deltopectoral flap, a novel approach combining endopharyngeal and external vacuum therapy was implemented.
Over six weeks, with vacuum system changes performed twice weekly, the pharyngocutaneous fistula successfully closed, leading to complete wound healing.
This case demonstrates the potential effectiveness of a combined endopharyngeal and external vacuum therapy approach for treating persistent pharyngocutaneous fistulas when conventional surgical options are exhausted. Notably, the patient was able to resume oral food consumption following therapy, highlighting the functional benefits of this novel treatment strategy.
如果能实现切缘清晰的可切除性,则考虑对复发性头颈癌患者进行挽救性手术。然而,术后并发症如伤口愈合障碍和咽皮肤瘘仍然是重大挑战。虽然存在各种重建手术技术,但已探索将外部和腔内支持性真空疗法作为一种替代治疗方式。
我们报告一例60岁复发性喉癌男性患者的病例,该患者在先前多次手术及确定性放化疗后接受了挽救性喉咽切除术。尽管使用胸大肌皮瓣、股前外侧皮瓣和筋膜皮瓣三角肌胸大肌皮瓣进行了多次重建,但仍持续形成咽皮肤瘘,于是实施了一种结合咽内和外部真空疗法的新方法。
在六周内,每周进行两次真空系统更换,咽皮肤瘘成功闭合,伤口完全愈合。
本病例表明,当传统手术选择用尽时,联合咽内和外部真空疗法治疗持续性咽皮肤瘘具有潜在有效性。值得注意的是,患者在治疗后能够恢复经口进食,突出了这种新治疗策略的功能益处。