用硫氢化钠将2,2'-二硝基联苯还原偶联成苯并[c]噌啉。
Reductive coupling of 2,2'-dinitrobiphenyls into benzo[c]cinnolines with NaHS.
作者信息
Yu Pingbing, Wen Zhaoyue, Wang Chun, Wu Jianlian, Chen Tie-Gen, Chen Wei
机构信息
Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.
Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
出版信息
Mol Divers. 2025 Feb 4. doi: 10.1007/s11030-024-11087-1.
An efficient and selective method for the reduction of 2,2'-dinitrobiphenyls with NaHS to prepare benzo[c]cinnoline and benzo[c]indole N-oxide was developed. This reductive coupling protocol proceeded as quick as 20 min, and gave moderate to good yields under ambient conditions. It was straightforward and easily scalable to produce various of benzo[c]cinnoline derivatives with diverse substitution patterns.
开发了一种用硫氢化钠还原2,2'-二硝基联苯以制备苯并[c]噌啉和苯并[c]吲哚N-氧化物的高效且选择性的方法。这种还原偶联反应在20分钟内即可完成，在环境条件下能获得中等至良好的产率。该方法操作简单，易于放大规模以制备具有不同取代模式的各种苯并[c]噌啉衍生物。
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