Dal Pont Tainah P, Santos Igor R, Pereira Vanessa C, Ferrari Flávia E, Schmidt Victória R Q, Bandinelli Marcele B, Alievi Marcelo Meller, Pavarini Saulo P
Setor de Patologia Veterinária, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Setor de Patologia Veterinária, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
J Comp Pathol. 2025 Feb;217:34-38. doi: 10.1016/j.jcpa.2025.01.004. Epub 2025 Feb 3.
A 2-year-old cockatiel (Nymphicus hollandicus) was presented with a large nodule on the ventral aspect of the right wing. Due to an accidental cutaneous trauma, the patient developed haemorrhage and subsequently died. The main necropsy finding was a pedunculated nodule that extended from the right pronator superficialis and biceps brachii muscles. Cytology of the nodule revealed neoplastic spindle cells with cytoplasmic cross-striations and multinucleate strap cells. Histologically, the nodule was composed of neoplastic spindle cells arranged in fascicles with a herringbone pattern. Neoplastic cells had multifocal cytoplasmic immunolabelling for vimentin and desmin, multifocal nuclear and cytoplasmic immunolabelling for myoblast determination protein 1 and rare cytoplasmic immunolabelling for α-smooth muscle actin. Neoplastic cells were negative for pancytokeratin. The final diagnosis was spindle cell rhabdomyosarcoma, a subtype rare in animals.
一只2岁的鸡尾鹦鹉（虎皮鹦鹉）右侧翅膀腹侧出现一个大结节。由于意外的皮肤创伤，该患者出现出血并随后死亡。尸检的主要发现是一个带蒂结节，从右肱桡肌和肱二头肌延伸。结节的细胞学检查显示肿瘤性梭形细胞，具有细胞质横纹和多核带状细胞。组织学上，结节由呈束状排列、具有人字形图案的肿瘤性梭形细胞组成。肿瘤细胞对波形蛋白和结蛋白有多处细胞质免疫标记，对成肌细胞决定蛋白1有多处核和细胞质免疫标记，对α-平滑肌肌动蛋白有罕见的细胞质免疫标记。肿瘤细胞对全细胞角蛋白呈阴性。最终诊断为梭形细胞横纹肌肉瘤，这是一种在动物中罕见的亚型。
