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Novel Function for Endothelial Protease-Activated Receptors in Modulating Insulin Receptor Activity With Implications for Diabetes.内皮蛋白酶激活受体在调节胰岛素受体活性中的新功能及其对糖尿病的影响。
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A novel function for endothelial protease-activated receptors in modulating insulin receptor activity with implications for diabetes.内皮蛋白酶激活受体在调节胰岛素受体活性方面的新功能及其对糖尿病的影响。
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本文引用的文献

1
Endothelial protease-activated receptor 4: impotent or important?内皮蛋白酶激活受体4：无作用还是重要？
Front Cardiovasc Med. 2025 Jan 28;12:1541879. doi: 10.3389/fcvm.2025.1541879. eCollection 2025.
2
Acetaminophen Overdose Reveals PAR4 as a Low-Expressing but Potent Receptor on the Hepatic Endothelium in Mice.对乙酰氨基酚过量揭示PAR4是小鼠肝内皮细胞上一种低表达但强效的受体。
Arterioscler Thromb Vasc Biol. 2025 Jan;45(1):53-71. doi: 10.1161/ATVBAHA.124.321353. Epub 2024 Oct 3.
3
The intrinsic substrate specificity of the human tyrosine kinome.人类酪氨酸激酶组的固有底物特异性。
Nature. 2024 May;629(8014):1174-1181. doi: 10.1038/s41586-024-07407-y. Epub 2024 May 8.
4
An atlas of substrate specificities for the human serine/threonine kinome.人类丝氨酸/苏氨酸激酶组的底物特异性图谱
Nature. 2023 Jan;613(7945):759-766. doi: 10.1038/s41586-022-05575-3. Epub 2023 Jan 11.
5
A journey from phosphotyrosine to phosphohistidine and beyond.从磷酸酪氨酸到磷酸组氨酸的历程及超越。
Mol Cell. 2022 Jun 16;82(12):2190-2200. doi: 10.1016/j.molcel.2022.05.007. Epub 2022 Jun 1.
6
The AMPK-related kinase NUAK2 suppresses glutathione peroxidase 4 expression and promotes ferroptotic cell death in breast cancer cells.与AMPK相关的激酶NUAK2抑制谷胱甘肽过氧化物酶4的表达并促进乳腺癌细胞的铁死亡。
Cell Death Discov. 2022 May 6;8(1):253. doi: 10.1038/s41420-022-01044-y.
7
Phosphoproteomic analysis of protease-activated receptor-1 biased signaling reveals unique modulators of endothelial barrier function.磷酸化蛋白质组学分析揭示了蛋白酶激活受体-1 偏向信号传导的内皮屏障功能的独特调节剂。
Proc Natl Acad Sci U S A. 2020 Mar 3;117(9):5039-5048. doi: 10.1073/pnas.1917295117. Epub 2020 Feb 18.
8
IKKβ regulates essential functions of the vascular endothelium through kinase-dependent and -independent pathways.IKKβ 通过激酶依赖和非依赖途径调节血管内皮的基本功能。
Nat Commun. 2011;2:318. doi: 10.1038/ncomms1317.
9
Loss of neuroprotective survival signal in mice lacking insulin receptor gene in rod photoreceptor cells.在视杆光感受器细胞中缺乏胰岛素受体基因的小鼠中神经保护性生存信号的丧失。
J Biol Chem. 2008 Jul 11;283(28):19781-92. doi: 10.1074/jbc.M802374200. Epub 2008 May 14.

Kinome profiling: A veritable Rosetta Stone for protease-activated receptor 1 biased signaling.

作者信息

Rajala Rahul, Griffin Courtney T

机构信息

Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States; Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States; Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.

Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States; Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.

出版信息

Vascul Pharmacol. 2025 Mar;158:107469. doi: 10.1016/j.vph.2025.107469. Epub 2025 Feb 2.

DOI:10.1016/j.vph.2025.107469
PMID:39904417
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11890924/
Abstract
摘要