Zhang Betty
Department of Medical Oncology, Sunshine Coast University Hospital, Birtinya, Queensland, Australia
Medical Oncology Research Fellow, Australian Rare Cancer Portal, The Royal Melbourne Hospital, Parkville, Victoria, Australia.
Drug Ther Bull. 2025 Mar 3;63(3):37-43. doi: 10.1136/dtb.2023.000059.
Cancer treatment is rapidly evolving and this review provides healthcare professionals who are not specialists in cancer therapeutics with a broad overview of the role of cancer systemic therapy, with a particular focus on chemotherapy.Historically, the majority of cytotoxic chemotherapy was used in patients with incurable or metastatic disease with the goal of disease control and symptom palliation. Now, with the advent of more effective, targeted systemic therapies (incorporating both cytotoxic and non-cytotoxic agents), systemic therapies are being used in more diverse treatment settings, both to increase the likelihood of cure and to induce prolonged disease remission.Chemotherapy (henceforth referring specifically to cytotoxic chemotherapy) remains important for the treatment of many cancer types. This article will review the principles of chemotherapy and the first-line systemic treatment paradigm of different cancer types. The potential toxicities of chemotherapy will also be described.
癌症治疗正在迅速发展，本综述为非癌症治疗领域专家的医疗保健专业人员提供了癌症全身治疗作用的广泛概述，尤其侧重于化疗。从历史上看，大多数细胞毒性化疗用于患有无法治愈或转移性疾病的患者，目的是控制疾病和缓解症状。如今，随着更有效、靶向性全身治疗（包括细胞毒性和非细胞毒性药物）的出现，全身治疗正被应用于更多样化的治疗场景，既用于提高治愈的可能性，也用于诱导疾病长期缓解。化疗（以下具体指细胞毒性化疗）对于许多癌症类型的治疗仍然很重要。本文将综述化疗的原则以及不同癌症类型的一线全身治疗模式。还将描述化疗的潜在毒性。
