Han Lei, Su Ning, Wu Chao, Yang Jiamin, Liu Xiaolin
Department of Radiology, The BaoTou Central Hospital, BaoTou, 01404, China.
Affiliated Baotou Clinical Medical College of Inner Mongolia Medical University, BaoTou, 014040, China.
Sci Rep. 2025 Feb 4;15(1):4246. doi: 10.1038/s41598-025-86997-7.
To measure the normal reference value of optic nerve sheath diameter (ONSD) and its correlation with eyeball transverse diameter (ETD), age and sex in Chinese adults by CT. The data of healthy adults who underwent head scan in Baotou Central Hospital from March 2022 to May 2023 were retrospectively collected. The ETD of both eyes and the ONSD (ONSD3mm, ONSD10mm) at 3 mm and 10 mm behind the eyeball were measured, and the relationship between ONSD and age, sex and ETD was analyzed by linear regression. A total of 360 subjects were included, 180 males and 180 females, aged 48.5 (33.00, 63.00) years. The average ONSD3mm, 10 mm and ETD of 360 included subjects were 5.28 (95% CI 5.23-5.32) mm, 4.34 (95% CI 4.30-4.37) mm and 22.47 (95% CI 22.38-22.56) mm, respectively. Univariate linear regression analysis showed that gender (P < 0.001) and ETD (P < 0.001) were the influencing factors of the mean ONSD. Further multivariate linear regression analysis also showed that gender (P < 0.001) and ETD (P < 0.01) were associated with ONSD values. The comparison of parameters between different genders showed that the values of all parameters in males were greater than those in females, and the difference between the two groups was statistically significant (P < 0.001). In addition, we further measured the ONSD/ETD values, which averaged 0.24 (0.23-0.24) at 3 mm and 0.19 (0.19-0.20) at 10 mm. The average ONSD3mm, 10 mm and ETD of healthy Chinese adults were 5.28 (95% CI 5.23-5.32) mm, 4.34 (95% CI 4.30-4.37) mm and 22.47 (95% CI 22.38-22.56) mm, respectively. At the same time, it is found that gender and ETD are the influencing factors of ONSD, and the diameter of ONSD is different between men and women.
通过CT测量中国成年人视神经鞘直径（ONSD）的正常参考值及其与眼球横径（ETD）、年龄和性别的相关性。回顾性收集2022年3月至2023年5月在包头市中心医院接受头部扫描的健康成年人的数据。测量双眼的ETD以及眼球后3mm和10mm处的ONSD（ONSD3mm、ONSD10mm），并通过线性回归分析ONSD与年龄、性别和ETD之间的关系。共纳入360名受试者，其中男性180名，女性180名，年龄48.5（33.00，63.00）岁。360名纳入受试者的平均ONSD3mm、10mm和ETD分别为5.28（95%CI 5.23 - 5.32）mm、4.34（95%CI 4.30 - 4.37）mm和22.47（95%CI 22.38 - 22.56）mm。单因素线性回归分析显示，性别（P＜0.001）和ETD（P＜0.001）是平均ONSD的影响因素。进一步的多因素线性回归分析也显示，性别（P＜0.001）和ETD（P＜0.01）与ONSD值相关。不同性别之间参数的比较显示，男性所有参数的值均大于女性，两组之间的差异具有统计学意义（P＜0.001）。此外，我们进一步测量了ONSD/ETD值，3mm处平均为0.24（0.23 - 0.24），10mm处平均为0.19（0.19 - 0.20）。健康中国成年人的平均ONSD3mm、10mm和ETD分别为5.28（95%CI 5.23 - 5.32）mm、4.34（95%CI 4.30 - 4.37）mm和22.47（95%CI 22.38 - 22.56）mm。同时发现，性别和ETD是ONSD的影响因素，且ONSD直径在男性和女性之间存在差异。
