Chen Han, Ding Gui-Sheng, Zhao Yan-Chun, Yu Rong-Guo, Zhou Jian-Xin
Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, No 6, TiantanXili, Dongcheng District, Beijing, 100050, China.
Surgical Intensive Care Unit, Fujian Provincial Clinical College, Fujian Medical University, No. 134, Dongjie Street, Gulou District, Fuzhou, Fujian, 350001, China.
BMC Neurol. 2015 Jul 7;15:106. doi: 10.1186/s12883-015-0361-x.
Measurement of optic nerve sheath diameter (ONSD) is a fast and non-invasive method in detecting elevated intracranial pressure. However, the reported normal range of ONSD was inconsistent. The objective of the study was to determine the normal range of ONSD in healthy Chinese adults.
Eyeball transverse diameter (ETD), optic nerve diameter (OND), and ONSD were measured by ultrasound examination in healthy adult volunteers. The OND and ONSD were assessed 3 mm behind the globe. The section showing maximal transverse diameter of the eyeball was frozen and the diameter was measured. Each ETD, OND and ONSD was examined twice and the mean value was calculated.
A total of 519 healthy volunteers were included in the study. The median (interquartile range) of ETD, OND and ONSD were 22.3 (21.6 to 23.1) mm, 3.2 (2.9 to 3.4) mm, and 5.1 (4.7 to 5.4) mm, respectively. The 95% percentile of ONSD was 5.9 mm. There was no significant difference in ETD, OND or ONSD between male and female, or between left and right eye. ONSD was significantly correlated with OND (r = 0.62, P < 0.001), and the median OND/ONSD ratio (interquartile range) was 0.63 (0.59 to 0.67).
The median and the 95% percentile of sonographic measurement of ONSD are 5.1 mm and 5.9 mm in healthy Chinese adults. The ONSD is correlated with OND, while independent of gender, age, height, weight and ETD. The median OND/ONSD ratio is 0.63 and this parameter warrants further investigation in patients with brain injury.
测量视神经鞘直径（ONSD）是检测颅内压升高的一种快速且非侵入性的方法。然而，报道的ONSD正常范围并不一致。本研究的目的是确定健康中国成年人的ONSD正常范围。
通过超声检查对健康成年志愿者测量眼球横径（ETD）、视神经直径（OND）和ONSD。在眼球后3mm处评估OND和ONSD。显示眼球最大横径的切片被冷冻并测量直径。每个ETD、OND和ONSD检查两次并计算平均值。
本研究共纳入519名健康志愿者。ETD、OND和ONSD的中位数（四分位间距）分别为22.3（21.6至23.1）mm、3.2（2.9至3.4）mm和5.1（4.7至5.4）mm。ONSD的第95百分位数为5.9mm。男性与女性之间或左右眼之间的ETD、OND或ONSD无显著差异。ONSD与OND显著相关（r = 0.62，P < 0.001），OND/ONSD中位数比值（四分位间距）为0.63（0.59至0.67）。
健康中国成年人超声测量ONSD的中位数和第95百分位数分别为5.1mm和5.9mm。ONSD与OND相关，而与性别、年龄、身高、体重和ETD无关。OND/ONSD中位数比值为0.63，该参数在脑损伤患者中值得进一步研究。
