Lushnikov E F, Andreev V G, Solov'eva L P
Med Radiol (Mosk). 1985 Apr;30(4):25-32.
The authors described clinicomorphological correlations in the evaluation of the efficacy of preoperative radiotherapy combined with metronidazole (MZ) in laryngeal cancer patients. A study was made of the tumors from 61 laryngeal cancer patients following radiation exposure at a summary dose of 20 and 32 Gy with and without MZ. Histological change of a tumor confirmed a radiosensitizing effect of MZ. However the MZ effect was not equally noticeable in tumor central and peripheral parts. Microscopic foci of the affected epithelium of the larynx and gland mucosa, muscular cells and vessels were revealed. MZ produces a stimulating effect on collagen production by fibroblasts.
作者描述了在评估术前放疗联合甲硝唑（MZ）对喉癌患者疗效时的临床形态学相关性。对61例喉癌患者的肿瘤进行了研究，这些患者接受了总剂量为20和32 Gy的辐射，部分患者使用了MZ，部分未使用。肿瘤的组织学变化证实了MZ的放射增敏作用。然而，MZ的作用在肿瘤中央和周边部分并不同样明显。发现了喉和腺体黏膜的受影响上皮、肌肉细胞和血管的微观病灶。MZ对成纤维细胞产生胶原的过程有刺激作用。
