Andreev V G
Med Radiol (Mosk). 1985 Aug;30(8):6-10.
The results of combined treatment of 98 laryngeal cancer patients followed up for 1.5-3 years were analysed. Of them 68 received a preoperative radiotherapy course combined with the electron acceptor compound metronidazole. The drug was given in the form of a sugar syrup suspension at a dose of 100-150 mg/kg bw 2.5-3 hours before each of the 4 fractions of irradiation, at 5 Gy twice a week reaching a summary focal dose of 20 Gy. Thirty patients received radiation therapy without metronidazole. Altogether 4 preoperative radiotherapy methods were used. An analysis of the results showed a significant improvement of the cure rates for laryngeal cancer patients using metronidazole, particularly for those with advanced stages. A better healing of postoperative wounds was noted. The author proved the appropriateness of preoperative irradiation by mean fractions up to a summary focal dose of 20 Gy combined with metronidazole and subsequent (on the last or next day of irradiation) radical operation.
对98例喉癌患者进行了1.5至3年的联合治疗随访结果分析。其中68例接受了术前放疗疗程，并联合电子受体化合物甲硝唑。该药物以糖浆悬浮液的形式给药，剂量为100 - 150毫克/千克体重，在4次放疗每次照射前2.5至3小时给药，每周两次，每次5 Gy，总局部剂量达到20 Gy。30例患者接受了不使用甲硝唑的放射治疗。总共使用了4种术前放疗方法。结果分析表明，使用甲硝唑的喉癌患者治愈率有显著提高，尤其是晚期患者。术后伤口愈合情况更好。作者证明了术前照射平均分次直至总局部剂量20 Gy联合甲硝唑并随后（在放疗最后一天或次日）进行根治性手术的合理性。
