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单独使用他克莫司软膏治疗儿童白癜风的安全性和有效性：一项系统评价和荟萃分析。

Safety and Efficacy of Tacrolimus Ointment Alone in the Treatment of Pediatric Vitiligo: A Systematic Review and Meta-Analysis.

作者信息

Alshaikh Alshaymaa Abdulrahman, Alshaikh Joud Abdulrahman, Alatawi Hind

机构信息

King Abdulaziz Medical City, Jeddah, Saudi Arabia.

King Abdulaziz University, Jeddah, Saudi Arabia.

出版信息

Biomed Hub. 2024 Dec 30;10(1):33-43. doi: 10.1159/000543311. eCollection 2025 Jan-Dec.

DOI:10.1159/000543311
PMID:39906121
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11793912/
Abstract

INTRODUCTION

Vitiligo, a skin disorder affecting melanocytes, poses treatment challenges. There is a need to investigate the role of tacrolimus in pediatric cases for its efficacy and safety. The present study aimed to assess the safety and efficacy of tacrolimus ointment in treating pediatric vitiligo patients.

METHODS

A review study was conducted, and a literature search was done on 2 August 2023, by using the words "vitiligo" and "tacrolimus" through five databases including PubMed. We found 8 studies from 930 records.

RESULTS

The rates of excellent, moderate, mild, minimal improvement, and no response were 29% (95% CI: 16-47), 26% (95% CI: 19-35), 28% (95% CI: 20-37), 19% (95% CI: 12-29), and 8% (95% CI: 2-25). No systemic side effects were reported. The overall prevalence of local side effects was 14% (95% CI: 7-24). Burning sensation prevalence was 11% (95% CI: 7-18), while pruritus prevalence was 9% (95% CI: 2-33). Study limitations encompassed varied vitiligo sites, patient demographics, and follow-up durations, lacked comparative treatment data, and necessitated further research on combined therapies, especially in pediatric cases.

CONCLUSION

Tacrolimus showed good efficacy regarding the re-pigmentation improvement in pediatric vitiligo patients. Furthermore, no systemic side effects were reported and local side effects were minimal mainly in the form of a burning sensation and pruritus.

摘要

引言

白癜风是一种影响黑素细胞的皮肤病，带来了治疗挑战。有必要研究他克莫司在儿科病例中的疗效和安全性。本研究旨在评估他克莫司软膏治疗儿童白癜风患者的安全性和疗效。

方法

进行了一项综述研究，并于2023年8月2日通过包括PubMed在内的五个数据库，使用“白癜风”和“他克莫司”等关键词进行了文献检索。我们从930条记录中找到了8项研究。

结果

显效、中度改善、轻度改善、轻微改善和无反应的比例分别为29%（95%置信区间：16 - 47）、26%（95%置信区间：19 - 35）、28%（95%置信区间：20 - 37）、19%（95%置信区间：12 - 29）和8%（95%置信区间：2 - 25）。未报告有全身副作用。局部副作用的总体发生率为14%（95%置信区间：7 - 24）。烧灼感发生率为11%（95%置信区间：7 - 18），而瘙痒发生率为9%（95%置信区间：2 - 33）。研究局限性包括白癜风部位不同、患者人口统计学特征和随访时间各异，缺乏对比治疗数据，并且需要对联合疗法进行进一步研究，尤其是在儿科病例中。

结论

他克莫司在改善儿童白癜风患者色素再生方面显示出良好疗效。此外，未报告有全身副作用，局部副作用主要为烧灼感和瘙痒，程度较轻。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c84d/11793912/05d7f4c02de2/bmh-2025-0010-0001-543311_F09.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c84d/11793912/187162f2a31a/bmh-2025-0010-0001-543311_F05.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c84d/11793912/05d7f4c02de2/bmh-2025-0010-0001-543311_F09.jpg

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本文引用的文献

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J Dermatolog Treat. 2024 Dec;35(1):2296851. doi: 10.1080/09546634.2023.2296851. Epub 2023 Dec 21.
2
Comparison of the efficacy of tacrolimus 0.1% ointment vs calcipotriol/betamethasone in combination with NBUVB in treatment of vitiligo.他克莫司 0.1%软膏与卡泊三醇/倍他米松联合窄谱中波紫外线治疗白癜风的疗效比较。
J Dermatolog Treat. 2023 Dec;34(1):2252119. doi: 10.1080/09546634.2023.2252119.
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Efficacy of topical tacrolimus 0.03% monotherapy in the treatment of non-segmental vitiligo: a randomized, controlled trial.
0.03% 外用他克莫司单药治疗非节段型白癜风的疗效：一项随机对照试验。
J Cosmet Dermatol. 2021 Dec;20(12):3943-3952. doi: 10.1111/jocd.14041. Epub 2021 Apr 17.
4
Efficacy of Tacrolimus Versus Clobetasol in the Treatment of Vitiligo.他克莫司与氯倍他索治疗白癜风的疗效比较
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