Palzkill Victoria R, Tan Jianna, Moparthy Divyansha, Tice Abigail L, Ferreira Leonardo F, Ryan Terence E
Department of Applied Physiology and Kinesiology, The University of Florida, Gainesville, Florida, USA.
Center for Exercise Science, The University of Florida, Gainesville, Florida, USA.
JACC Basic Transl Sci. 2024 Oct 23;10(1):88-103. doi: 10.1016/j.jacbts.2024.08.011. eCollection 2025 Jan.
In this study, we present a novel 6-minute limb function test that allows for the congruent assessment of muscular performance and hemodynamics in preclinical models of peripheral artery disease. Using several experimental conditions, the results demonstrate the superior efficacy of the 6-minute limb function test to detect differences in the response to hindlimb ischemia across several interventions, including where traditional perfusion recovery, capillary density, and muscle strength measures were unable to detect interventional differences, thus allowing for more rigorous assessment of preclinical therapies before clinical translation.
在本研究中，我们提出了一种新型的6分钟肢体功能测试，该测试能够在外周动脉疾病临床前模型中对肌肉性能和血流动力学进行一致的评估。通过几种实验条件，结果表明6分钟肢体功能测试在检测多种干预措施对后肢缺血反应差异方面具有卓越的功效，包括在传统的灌注恢复、毛细血管密度和肌肉力量测量无法检测到干预差异的情况下，从而能够在临床转化之前对临床前治疗进行更严格的评估。
