Saravanan Kothandan, Keshri Neha, Nandeesha Hanumanthappa, Menon Vikas, Goud Alladi Charanraj
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Department of Psychiatry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
J Neurosci Rural Pract. 2022 Oct-Dec;13(4):691-695. doi: 10.25259/JNRP-2022-6-34. Epub 2022 Oct 22.
Plasticity of neural synapses is known to be involved in the complications in bipolar disorder (BD) patients. Matrix metalloproteinases (MMPs) play a role in synaptic plasticity and memory. Even though elevated MMP-9 levels are reported in neuropsychiatric disorders, there is limited data about MMP-9 gene polymorphism in BD. The objectives of the study was to investigate genotype frequency and allele frequency of MMP-9 genetic variant (rs 17576) in BD and its association with disease severity.
Eighty BD cases and 80 controls were recruited in the study. MMP-9 genotyping and allele frequency and plasma MMP-9 levels were analyzed in both the groups. Hamilton depression rating scale and Young's Mania Rating Scale (YMRS) were used to evaluate severity of BD.
The genotype and minor allele (G allele) frequency were not significant between BD and controls. MMP-9 levels were significantly increased in BD patients with AG ( < 0.001) and GG ( = 0.022) genotypes compared to controls. BD patients with GG genotype ( = 0.038, OR: 3.26 (1.16-9.09), and G (mutant) allele ( = 0.013, OR 2.03(1.18-3.48) confer increased risk of depressive symptoms. MMP-9 was positively correlated with YMRS scale (r = 0.227, = 0.043) in BD.
MMP-9 gene polymorphism (rs 17576) is linked with depressive symptoms in BD.
已知神经突触可塑性与双相情感障碍（BD）患者的并发症有关。基质金属蛋白酶（MMPs）在突触可塑性和记忆中发挥作用。尽管在神经精神疾病中报告了MMP-9水平升高，但关于BD中MMP-9基因多态性的数据有限。本研究的目的是调查BD中MMP-9基因变异（rs 17576）的基因型频率和等位基因频率及其与疾病严重程度的关联。
本研究招募了80例BD患者和80名对照。对两组进行MMP-9基因分型、等位基因频率和血浆MMP-9水平分析。采用汉密尔顿抑郁评定量表和杨氏躁狂评定量表（YMRS）评估BD的严重程度。
BD组和对照组之间的基因型和次要等位基因（G等位基因）频率无显著差异。与对照组相比，AG（<0.001）和GG（=0.022）基因型的BD患者MMP-9水平显著升高。GG基因型（=0.038，OR：3.26（1.16 - 9.09））和G（突变）等位基因（=0.013，OR 2.03（1.18 - 3.48））的BD患者出现抑郁症状的风险增加。BD患者中MMP-9与YMRS量表呈正相关（r = 0.227，= 0.043）。
MMP-9基因多态性（rs 175
