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老年人髋关节囊外和囊内骨折的病因及临床结局:一项性别特异性分析。

Etiological factors and clinical outcomes in extracapsular and intracapsular hip fractures among older adults: A gender-specific analysis.

作者信息

Lisk Radcliffe, Yeong Keefai, Fluck David, Robin Jonathan, Fry Christopher H, Han Thang S

机构信息

Department of Orthopaedic Trauma, Ashford and St Peter's NHS Foundation Trust, Chertsey, UK.

Department of Cardiology, Ashford and St Peter's NHS Foundation Trust, Chertsey, UK.

出版信息

PM R. 2025 Jul;17(7):793-803. doi: 10.1002/pmrj.13326. Epub 2025 Feb 5.

Abstract

BACKGROUND

Compared to patients with intracapsular fractures (ICFs), those with extracapsular fractures (ECFs) had worse outcomes. However, most studies of risk factors for these fractures lacked relevant potential reasons, particularly nutritional status, and adjustment for confounding factors. Furthermore, less is known about their effects on clinical outcomes.

OBJECTIVE

To conduct a gender-specific analysis of community-dwelling individuals admitted with hip fractures to examine the association of clinical risk factors and health care measures.

DESIGN

Monocentric cross-sectional study.

SETTING

Orthopedic trauma department.

PARTICIPANTS

A total of 787 women and 318 men of similar mean age (±SD): 83.1 years (±8.6) and 82.5 years (±9.0), respectively.

MAIN OUTCOME MEASURES

Multivariable logistic regression analyzed risk factors including age, gender, dementia, stroke, ischemic heart disease, diabetes, prefracture mobility, alcohol consumption, American Society of Anesthesiologists grades, drug history, and nutrition status for assessing risk factors and outcomes associated with ECFs and ICFs.

RESULTS

Compared to ICFs, for each additional year of age, women had a 3% and men 4% greater association with ECFs. Among women only, ECFs were associated with risk of malnutrition: odds ratio [OR] = 1.70 (95% CI, 1.17-2.48) or malnourishment: OR = 1.93 (95% CI, 1.06-3.52), stroke: OR = 1.85 (95% CI, 1.16-2.97), and diabetes: OR = 1.92 (95% CI, 1.21-3.06). Women with ECFs were less likely to be discharged to their own homes: OR = 0.56 (95% CI, 0.38-0.83); but more likely to be discharged to a rehabilitation unit: OR = 1.81 (95% CI, 1.21-2.71) and readmitted to hospital within 30 days of discharge ≥1 time: OR: 2.39 (95% CI, 1.27-4.50) or ≥2 times: OR = 3.48 (95% CI, 1.05-11.57): they did not differ in discharge to residential or nursing care or in-hospital mortality. Among men, there were no differences in discharge destinations or readmissions between types of fractures.

CONCLUSIONS

Compared to ICFs, a greater number of risk factors associated with ECFs were identified more often in women than in men, and ECFs also have greater influences on clinical outcomes in women.

摘要

背景

与囊内骨折(ICF)患者相比,囊外骨折(ECF)患者的预后更差。然而,大多数关于这些骨折危险因素的研究缺乏相关的潜在原因,特别是营养状况,以及对混杂因素的调整。此外,人们对它们对临床结局的影响了解较少。

目的

对因髋部骨折入院的社区居民进行性别特异性分析,以研究临床危险因素与医疗保健措施之间的关联。

设计

单中心横断面研究。

地点

骨科创伤科。

参与者

总共787名女性和318名男性,平均年龄相似(±标准差):分别为83.1岁(±8.6)和82.5岁(±9.0)。

主要观察指标

多变量逻辑回归分析了包括年龄、性别、痴呆、中风、缺血性心脏病、糖尿病、骨折前活动能力、饮酒量、美国麻醉医师协会分级、用药史和营养状况等危险因素,以评估与ECF和ICF相关的危险因素及结局。

结果

与ICF相比,女性年龄每增加一岁,发生ECF的关联度增加3%,男性增加4%。仅在女性中,ECF与营养不良风险相关:比值比[OR]=1.70(95%可信区间,1.17 - 2.48)或营养不足:OR = 1.93(95%可信区间,1.06 - 3.52)、中风:OR = 1.85(95%可信区间,1.16 - 2.97)和糖尿病:OR = 1.92(95%可信区间,1.21 - 3.06)。发生ECF的女性出院回家的可能性较小:OR = 0.56(95%可信区间,0.38 - 0.83);但更有可能出院到康复机构:OR = 1.81(95%可信区间,1.21 - 2.71),并且在出院后30天内再次入院≥1次:OR:2.39(95%可信区间,1.27 - 4.50)或≥2次:OR = 3.48(95%可信区间,1.05 - 11.57):她们在出院到寄宿或护理机构或住院死亡率方面没有差异。在男性中,不同类型骨折之间的出院目的地或再入院情况没有差异。

结论

与ICF相比,女性中与ECF相关的危险因素比男性更多,并且ECF对女性临床结局的影响也更大。

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