Mombo Landry Erick, Moreau Brice d'Aquin, Bisseye Cyrille, Mikelet Boussoukou Ismaël Pierrick, Mongo Delis Arnaud, Lendamba Roméo Wenceslas, Kassa Kassa Roland Fabrice, Iyedi Likouahan Romuald
Laboratoire de Biologie Moléculaire et Cellulaire (LABMC), Université des Sciences et Techniques de Masuku (USTM), BP 901, Franceville, Gabon.
Centre de Traitement Ambulatoire (CTA) de Koula-Moutou, Koula-Moutou, Gabon.
Int J Hematol. 2025 May;121(5):653-657. doi: 10.1007/s12185-025-03934-0. Epub 2025 Feb 5.
Sickle cell anemia remains a major public health problem in Gabon, with high mortality. However, its prevalence is mainly documented in the capital city of Libreville, with few data for other areas.
We performed diagnostic testing by electrophoresis on 1534 individuals from two sites in eastern Gabon: Franceville and Koula-Moutou. We also screened 791 individuals from Koula-Moutou using a method that combines hemoglobin levels with leukocyte counts.
The allelic frequency of the hemoglobin S and C genes were 18.5% and 0.07%, respectively, in areas of eastern Gabon. Also 3.7% of individuals had sickle cell disease, 29.8% had sickle cell trait and 0.1% was heterozygous for hemoglobin AC. The diagnostic orientation method used in our study showed a sensitivity of 100%, a specificity of 97.4%, and a negative predictive value of 100%.
This method using hemogram data has proved to be valuable in areas with high resource constraints, and could be used in other areas to aid diagnostic orientation. It would be interesting to similarly evaluate the frequency of sickle cell anaemia in the northern and southern regions of Gabon.
镰状细胞贫血在加蓬仍是一个重大的公共卫生问题，死亡率很高。然而，其患病率主要记录在首都利伯维尔，其他地区的数据很少。
我们对来自加蓬东部两个地点（弗朗斯维尔和库拉穆图）的1534人进行了电泳诊断测试。我们还使用一种将血红蛋白水平与白细胞计数相结合的方法对来自库拉穆图的791人进行了筛查。
在加蓬东部地区，血红蛋白S和C基因的等位基因频率分别为18.5%和0.07%。此外，3.7%的个体患有镰状细胞病，29.8%的个体具有镰状细胞性状，0.1%的个体为血红蛋白AC杂合子。我们研究中使用的诊断导向方法显示敏感性为100%，特异性为97.4%，阴性预测值为100%。
这种使用血常规数据的方法已被证明在资源高度有限的地区很有价值，并且可用于其他地区以辅助诊断导向。类似地评估加蓬北部和南部地区镰状细胞贫血的频率将是很有意思的。
