Rolland Simon, Nguyen Lb Luong, Descamps A, Galtier F, Duval X, Vanhems P, Lainé F, Tattevin P, Bauer R, Launay O
INSERM, CIC 1417; AP-HP, Cochin Hospital, CIC Cochin Pasteur, Paris, France; Infectious and Tropical Diseases Department, Cavale Blanche Hospital, Brest University Hospital, Brest, France.
INSERM, CIC 1417; AP-HP, Cochin Hospital, CIC Cochin Pasteur, Paris, France.
Int J Infect Dis. 2025 Apr;153:107811. doi: 10.1016/j.ijid.2025.107811. Epub 2025 Feb 3.
This study aimed to estimate influenza and pneumococcal vaccination coverage among adults hospitalized with severe acute respiratory infections in France from 2016 to 2022 and to analyze factors associated with vaccination.
We analyzed data from a prospective multicenter study involving adults hospitalized with severe acute respiratory infections. Descriptive and comparative analyses of influenza and pneumococcal vaccination coverage were conducted along with multivariate logistic regression to identify the factors associated with vaccination.
We included 4,614 patients; 88% (4,080/4,614) had an indication for influenza vaccination. Among them, 2,181/4,080 (53%) were vaccinated against influenza. Factors associated with vaccination included age ≥65 years (adjusted odds ratio [aOR] 3.05; 95% confidence interval [CI] 2.63-3.55) and chronic respiratory diseases (aOR 1.38; 95% CI 1.20-1.59). Pneumococcal vaccination status was available for 90% (4,142/4,614) of patients, of whom 71% (2,920/4,142) had an indication for vaccination. Pneumococcal vaccination coverage was 19% (551/2,920). The factors associated with vaccination were chronic respiratory disease (aOR 2.74; 95% CI 2.22-3.40) and immunocompromised conditions other than malignancies. The vaccination coverage for each vaccine did not increase over time. Among the 3,247 patients eligible for both vaccines, 13% received both vaccines.
In this high-risk population, the vaccination coverage was low, particularly with pneumococcal vaccines. Therefore, improved vaccination recommendation strategies and communication are required.
本研究旨在估计2016年至2022年期间在法国因严重急性呼吸道感染住院的成年人中流感疫苗和肺炎球菌疫苗的接种覆盖率，并分析与疫苗接种相关的因素。
我们分析了一项前瞻性多中心研究的数据，该研究涉及因严重急性呼吸道感染住院的成年人。对流感疫苗和肺炎球菌疫苗接种覆盖率进行了描述性和比较性分析，并进行了多因素逻辑回归分析，以确定与疫苗接种相关的因素。
我们纳入了4614名患者；88%（4080/4614）有接种流感疫苗的指征。其中，2181/4080（53%）接种了流感疫苗。与疫苗接种相关的因素包括年龄≥65岁（调整后的优势比[aOR]为3.05；95%置信区间[CI]为2.63-3.55）和慢性呼吸道疾病（aOR为1.38；95%CI为1.20-1.59）。90%（4142/4614）的患者有肺炎球菌疫苗接种状态数据，其中71%（2920/4142）有接种指征。肺炎球菌疫苗接种覆盖率为19%（551/2920）。与疫苗接种相关的因素是慢性呼吸道疾病（aOR为2.74；95%CI为2.22-3.40）和除恶性肿瘤外的免疫功能低下状况。每种疫苗的接种覆盖率并未随时间增加。在3247名符合两种疫苗接种条件的患者中，13%接种了两种疫苗。
在这个高危人群中，疫苗接种覆盖率较低，尤其是肺炎球菌疫苗。因此，需要改进疫苗接种推荐策略和沟通。
