Bonanno G, Marchi M, Raiteri M
Neuropharmacology. 1985 Mar;24(3):261-4. doi: 10.1016/0028-3908(85)90083-8.
The release of endogenous dopamine was investigated using rat striatal synaptosomes in superfusion. Depolarization with 15 mM KC1 evoked a release which was totally calcium-dependent. Also, the basal release of dopamine was in part dependent on the presence of calcium ions. Exogenous acetylcholine potentiated the K+-induced release of endogenous dopamine through the activation of receptors of the muscarinic type located on dopamine nerve terminals. Very similar results were obtained when the release of 3H-dopamine, previously taken up into striatal synaptosomes, was examined.
