Raiteri M, Marchi M, Maura G
Eur J Pharmacol. 1982 Sep 10;83(1-2):127-9. doi: 10.1016/0014-2999(82)90296-5.
The effects of acetylcholine on the release of [3H]dopamine was studied in superfused rat striatal synaptosomes prelabeled with the radioactive amine. The results confirm the presence of muscarinic presynaptic receptors mediating potentiation of the spontaneous release of the catecholamine. However, under depolarizing conditions, the release of dopamine evoked by 15 mM KC1 was increased by the activation of muscarinic receptors and not decreased, as previously found in striatal synaptosomes or slices depolarized with higher (50-60 mM) KC1 concentrations.
在预先用放射性胺标记的大鼠纹状体突触体的灌流液中，研究了乙酰胆碱对[3H]多巴胺释放的影响。结果证实存在毒蕈碱型突触前受体，其介导儿茶酚胺自发释放的增强。然而，在去极化条件下，15 mM氯化钾诱发的多巴胺释放通过毒蕈碱受体的激活而增加，而非如先前在使用较高（50 - 60 mM）氯化钾浓度去极化的纹状体突触体或切片中所发现的那样减少。
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