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用于声动力治疗的声敏剂：当前进展与未来展望

Sonosensitizers for Sonodynamic Therapy: Current Progress and Future Perspectives.

作者信息

Wang Ting, Du Meng, Chen Zhiyi

机构信息

Key Laboratory of Medical Imaging Precision Theranostics and Radiation Protection, College of Hunan Province, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China; Institute of Medical Imaging, Hengyang Medical School, University of South China, Hengyang, China; Department of Medical Imaging, the Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.

出版信息

Ultrasound Med Biol. 2025 May;51(5):727-734. doi: 10.1016/j.ultrasmedbio.2025.01.011. Epub 2025 Feb 5.

DOI:10.1016/j.ultrasmedbio.2025.01.011

PMID:39909788

Abstract

Sonodynamic therapy (SDT) is a novel non-invasive treatment method that combines low-intensity ultrasound and sonosensitizers. Compared with photodynamic therapy, SDT has the advantages of deeper tissue penetration, higher accuracy and fewer adverse reactions. Sonosensitizers are essential for the efficacy of SDT. Sonosensitizers have the advantages of clear structure, easy monitoring, evaluation of drug metabolism and clinical transformation, etc. Notably, biochemical techniques can be used in the field of sonosensitizers and SDT to overcome inherent barriers and achieve sustainable innovation. This article first summarizes the molecular mechanism of SDT, focusing on organic sonosensitizers, inorganic nano-sonosensitizers and multi-functional drug delivery systems with targeting, penetration and imaging functions after a series of modifications. This review provides ideas and references for the design of sonosensitizers and SDT and promotes their future transformation into clinical applications.

摘要

声动力疗法（SDT）是一种将低强度超声与声敏剂相结合的新型非侵入性治疗方法。与光动力疗法相比，SDT具有组织穿透更深、准确性更高和不良反应更少的优点。声敏剂对SDT的疗效至关重要。声敏剂具有结构清晰、易于监测、药物代谢评估和临床转化等优点。值得注意的是，生化技术可用于声敏剂和SDT领域，以克服固有障碍并实现可持续创新。本文首先总结了SDT的分子机制，重点介绍了经过一系列修饰后具有靶向、穿透和成像功能的有机声敏剂、无机纳米声敏剂和多功能药物递送系统。本综述为声敏剂和SDT的设计提供了思路和参考，并促进它们未来向临床应用的转化。