Khalil Shahd, Quran Aseel, Thalji Leen, Al-Adamat Malk, Sabha Lina, Khraisat Joud, Al Na'ami Abdel Rahman, Al-Jazzazi Hatem, Alhawari Hussein, Jarrar Yazun
Department of Basic Medical Sciences, Faculty of Medicine, Al-Balqa Applied University, Al-Salt, Jordan.
Department of Internal Medicine, School of Medicine, The University of Jordan, Amman, Jordan.
Drug Metab Pers Ther. 2025 Feb 6;40(1):69-75. doi: 10.1515/dmpt-2024-0088. eCollection 2025 Mar 1.
There is an inter-individual in the valsartan response among hypertensive patients. However, clinical factors associated with this variation in the response is still not fully understood. The major purpose of this study is to predict the factors associated with valsartan response and their influence on decreasing blood pressure among patients.
This study is a cross-sectional observational study. It included 91 hypertensive patients on valsartan treatment, selected through simple random sampling from the Jordan University Hospital. The clinical data was collected through documented medical records in the hospital's computerized system. The data was analyzed using the chi-square test to compare frequencies and categories.
Patients were divided into systolic and diastolic responders. No statistical significance was found between systolic response to valsartan's and gender, smoking, age, BMI, lipid profile and HbA status. Diastolic responders had a positive significance of p-value = 0.006 with BMI categories, however there was no significance with any other factor.
There was a better diastolic response to valsartan among hypertensive patients with lower BMI levels. BMI can be considered as a factor to personalize the therapy among patients on valsartan. However, further clinical studies with larger sample size are needed to confirm these data.
高血压患者对缬沙坦的反应存在个体差异。然而，与这种反应差异相关的临床因素仍未完全明确。本研究的主要目的是预测与缬沙坦反应相关的因素及其对患者血压降低的影响。
本研究为横断面观察性研究。纳入了91例接受缬沙坦治疗的高血压患者，通过简单随机抽样从约旦大学医院选取。临床数据通过医院计算机系统中的病历记录收集。使用卡方检验分析数据以比较频率和类别。
患者被分为收缩压反应者和舒张压反应者。缬沙坦的收缩压反应与性别、吸烟、年龄、BMI、血脂谱和糖化血红蛋白状态之间未发现统计学意义。舒张压反应者与BMI类别之间的p值具有显著意义（p值 = 0.006），但与其他任何因素均无显著意义。
BMI水平较低的高血压患者对缬沙坦的舒张压反应较好。BMI可被视为缬沙坦治疗患者个体化治疗的一个因素。然而，需要进一步开展更大样本量的临床研究来证实这些数据。
