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[兔胎儿睾丸中抑制生殖母细胞分裂的因子]

[Factor inhibiting gonocyte division in the testes of the rabbit fetus].

作者信息

Brindak O I, Aleshin B V, Malyshev A B

出版信息

Ontogenez. 1985 Mar-Apr;16(2):162-6.

PMID:3991111
Abstract

A factor of protein nature selectively inhibiting the division of gonocytes was isolated from the extracts of testes of the 27 and 29 day old rabbit foetuses by the method of gel-chromatography with Sephadex G-100. Its molecular mass equals 30 000. This factor is also present in the testes of newborn, one month old and adult rabbits. It appears to be involved in the local mechanisms of regulation of spermatogenesis, unlike inhibin acting via the central mechanisms affecting the FSH and LH secretion by the pituitary.

摘要

采用Sephadex G - 100凝胶色谱法,从27日龄和29日龄兔胎儿睾丸提取物中分离出一种具有蛋白质性质、能选择性抑制生殖母细胞分裂的因子。其分子量为30000。该因子在新生兔、1月龄兔和成年兔的睾丸中也存在。与通过影响垂体促卵泡激素(FSH)和促黄体生成素(LH)分泌的中枢机制起作用的抑制素不同,它似乎参与了精子发生的局部调节机制。

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