Koike S, Jost A
C R Seances Acad Sci III. 1982 Dec 6;295(12):701-5.
The production of müllerian inhibitor (or anti-müllerian hormone) by the testes of the Rabbit fetus was studied in vitro by co-culturing them with castrated genital tracts from 14.5 day old female Rat fetuses for three days. Under these conditions testes from 14 day old Rabbit fetuses were inactive. The testes from 15, 16 and 17 day old fetuses in which seminiferous cords are forming, had anti-müllerian activity, the older the stronger. In vivo this activity does not prevent the Müllerian ducts from growing in male Rabbits as well as in females until near to day 20; in vitro the fetal Rat ducts also grew in length despite the testicular anti-müllerian activity.
通过将兔胎儿的睾丸与14.5日龄雌性大鼠胎儿的去势生殖道共培养三天，对兔胎儿睾丸中苗勒管抑制物（或抗苗勒管激素）的产生进行了体外研究。在这些条件下，14日龄兔胎儿的睾丸无活性。15、16和17日龄胎儿的睾丸正在形成生精索，具有抗苗勒管活性，年龄越大活性越强。在体内，这种活性直到接近第20天时才会阻止雄性和雌性兔的苗勒管生长；在体外，尽管睾丸具有抗苗勒管活性，但大鼠胎儿的生殖道仍会伸长。
