Kraff M C, Sanders D R, Jampol L M, Lieberman H L
Ophthalmology. 1985 Mar;92(3):366-9. doi: 10.1016/s0161-6420(85)34024-1.
A prospective double-masked study of 301 patients was undertaken to compare the effect of ultraviolet (UV) filtering in implant intraocular lenses (IOL) on the angiographic incidence of cystoid macular edema (CME) in patients undergoing extracapsular cataract extraction. Patients were randomized to receive either a posterior chamber IOL that contained UV-absorbing chromophore or an identical IOL which did not contain such a chromophore. All patients were scheduled for fluorescein angiography between three and six months after surgery; 228 angiograms were obtained that were readable for the presence or absence of angiographic CME. The mean interval following surgery was 4.3 months. The incidence of CME was 18.8% (21 of 112) in patients who received lenses without UV-filtering chromophore and 9.5% (11 of 116) in patients who received IOLs that contained UV-filtering chromophore. These findings show that UV-filtering-IOLs resulted in a statistically significant (P = 0.03) decrease in the incidence of CME. The presence or absence of the UV-filtering chromophore did not, however, significantly affect visual acuity in the early postoperative period.
对301例患者进行了一项前瞻性双盲研究，以比较植入式人工晶状体（IOL）中的紫外线（UV）滤过对接受白内障囊外摘除术患者囊样黄斑水肿（CME）血管造影发生率的影响。患者被随机分为两组，分别接受含有紫外线吸收发色团的后房型人工晶状体或不含该发色团的相同人工晶状体。所有患者均计划在术后三至六个月进行荧光素血管造影；共获得228份可用于判断是否存在血管造影性CME的血管造影片。术后平均间隔时间为4.3个月。接受无紫外线滤过发色团晶状体的患者中CME发生率为18.8%（112例中的21例），接受含有紫外线滤过发色团人工晶状体的患者中CME发生率为9.5%（116例中的11例）。这些结果表明，紫外线滤过人工晶状体使CME发生率在统计学上显著降低（P = 0.03）。然而，紫外线滤过发色团的有无在术后早期对视力并无显著影响。
