Ali Syed Muhammad Hammad, Khan Haseeb Ahmed, Malik Asim, Ali Sana, Hussain Ahmad
Surgery, Fatima Memorial Hospital College of Medicine & Dentistry, Lahore, PAK.
Pathology, Fatima Memorial Hospital College of Medicine & Dentistry, Lahore, PAK.
Cureus. 2025 Jan 6;17(1):e77013. doi: 10.7759/cureus.77013. eCollection 2025 Jan.
Ovarian carcinoid tumors, originating from mature ovarian cystic teratomas (dermoid cysts), are rare neuroendocrine tumors. The synchronous occurrence of trabecular and mucinous carcinoid tumors within a single ovarian teratoma is infrequent and has limited documentation. We present the case of a 67-year-old postmenopausal woman presenting with abdominal pain, constipation, and urinary retention, but without features of carcinoid syndrome. Ultrasonography identified a complex, multiloculated cystic mass in the right ovary. Laboratory assessments, including CA-125 levels, were unremarkable. The cyst was aspirated and surgically excised, with the patient experiencing an uncomplicated recovery. Histopathological and immunohistochemical analyses confirmed a mixed trabecular and mucinous carcinoid tumor within the teratoma. A six-month follow-up ultrasound revealed no recurrence, and the patient remained symptom-free. This case highlights the importance of considering synchronous, asymptomatic carcinoid tumors in mature ovarian teratomas during gross and histopathological examinations. Additionally, the presence of a mucinous carcinoid should warrant a high suspicion of metastasis and subsequent recurrence. Further research is needed to establish management and recurrence monitoring guidelines.
卵巢类癌肿瘤起源于成熟的卵巢囊性畸胎瘤（皮样囊肿），是罕见的神经内分泌肿瘤。单个卵巢畸胎瘤内同时出现小梁状和黏液性类癌肿瘤的情况并不常见，且文献记载有限。我们报告一例67岁绝经后女性病例，该患者表现为腹痛、便秘和尿潴留，但无类癌综合征特征。超声检查发现右卵巢有一个复杂的多房囊性肿块。包括CA - 125水平在内的实验室检查结果无异常。对囊肿进行了抽吸和手术切除，患者恢复过程顺利。组织病理学和免疫组织化学分析证实畸胎瘤内存在混合性小梁状和黏液性类癌肿瘤。六个月后的随访超声检查未发现复发，患者仍无症状。该病例强调了在大体和组织病理学检查中考虑成熟卵巢畸胎瘤内同步无症状类癌肿瘤的重要性。此外，黏液性类癌的存在应高度怀疑转移及随后的复发。需要进一步研究以制定管理和复发监测指南。
