Goswami Mridula, Sultan Farheen, Singh Archana
Pediatric and Preventive Dentistry, Maulana Azad Institute of Dental Sciences, New Delhi, IND.
Cureus. 2025 Jan 5;17(1):e76982. doi: 10.7759/cureus.76982. eCollection 2025 Jan.
Osteogenesis imperfecta (OI) is a rare genetic condition marked by brittle bones and various degrees of skeletal deformity. It is also referred to as brittle bone disease. There are four forms of OI, and its management relies on preventing fractures and increasing bone strength, which becomes more difficult when treating a juvenile patient in a dental setting. A six-year-old child with OI, type 1, with a history of recurrent multiple fractures, complained of pain in his mandibular teeth. The patient was receiving biannual bisphosphonate injections for OI. During the initial dental appointment, the patient was apprehensive and afraid, but cooperative behavior was achieved using non-pharmacological behavior management techniques. Full mouth rehabilitation was done while restoring the vitality of carious permanent teeth using regenerative endodontic therapy. The patient was then followed up on a regular basis to ensure progressive apical root closure. Regenerative endodontics uses the concept of tissue engineering to restore the root canals to a healthy state, allowing for the continued development of the root and surrounding tissue. This case report discusses the issues in managing a pediatric patient with OI as well as the benefits of regenerative endodontic treatment therapy in preserving tooth vitality.
成骨不全症（OI）是一种罕见的遗传性疾病，其特征为骨骼脆弱及不同程度的骨骼畸形。它也被称为脆骨病。OI有四种类型，其治疗主要依靠预防骨折和增强骨强度，而在牙科环境中治疗青少年患者时，这变得更加困难。一名患有1型OI的六岁儿童，有反复多次骨折史，主诉下颌牙齿疼痛。该患者因OI每半年接受一次双膦酸盐注射。在初次牙科就诊时，患者感到焦虑和害怕，但通过非药物行为管理技术实现了合作行为。在使用再生牙髓治疗恢复龋坏恒牙活力的同时进行了全口修复。随后对患者进行定期随访，以确保根尖逐步闭合。再生牙髓治疗利用组织工程的概念将根管恢复到健康状态，使牙根和周围组织能够持续发育。本病例报告讨论了管理患有OI的儿科患者的问题以及再生牙髓治疗在保持牙齿活力方面的益处。
