Kosekli Mehmet Ali, Aktas Gulali
Department of Gastroenterology, Abant Izzet Baysal University Hospital, Bolu, Turkey.
Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey.
Curr Med Res Opin. 2025 Feb;41(2):247-251. doi: 10.1080/03007995.2025.2463952. Epub 2025 Feb 12.
Metabolic dysfunction-associated fatty liver disease (MAFLD) can trigger inflammation, hepatocellular damage, cirrhosis, and hepatocellular carcinoma. There is a need for non-invasive, cost-effective diagnostic markers for MAFLD, as current methods like liver biopsy are invasive. This study investigates the potential of the systemic immune inflammation index (SII) as a useful tool in diagnosis of MAFLD.
A cohort of 806 individuals, including 426 with MAFLD and 380 controls, was analyzed. SII values, along with various biochemical and inflammatory markers, were compared between groups.
The MAFLD group exhibited significantly higher SII values, which correlated with key markers of liver inflammation and function. Median SII levels of the MAFLD patients (581 (45-4553)) were significantly higher than that of the control group (423 (112-2595)) ( <0.001). SII showed moderate sensitivity (72%) and specificity (56%) in detecting MAFLD. Logistic regression analysis identified SII as an independent risk factor for MAFLD, with a unit increase in SII increasing the risk by 1.21 times.
These findings suggest that SII could serve as a useful, noninvasive marker for diagnosing and monitoring MAFLD, warranting further longitudinal studies to explore its role in disease progression and treatment response.
代谢功能障碍相关脂肪性肝病（MAFLD）可引发炎症、肝细胞损伤、肝硬化和肝细胞癌。由于目前诸如肝活检等方法具有侵入性，因此需要用于MAFLD的非侵入性、具有成本效益的诊断标志物。本研究调查了全身免疫炎症指数（SII）作为诊断MAFLD有用工具的潜力。
分析了一组806名个体，其中包括426例MAFLD患者和380名对照。比较了各组之间的SII值以及各种生化和炎症标志物。
MAFLD组的SII值显著更高，且与肝脏炎症和功能的关键标志物相关。MAFLD患者的SII中位数水平（581（45 - 4553））显著高于对照组（423（112 - 2595））（<0.001）。SII在检测MAFLD方面表现出中等敏感性（72%）和特异性（56%）。逻辑回归分析确定SII是MAFLD的独立危险因素，SII每增加一个单位，风险增加1.21倍。
这些发现表明，SII可作为诊断和监测MAFLD的有用的非侵入性标志物，需要进一步进行纵向研究以探索其在疾病进展和治疗反应中的作用。
