Yu Chenyang, Yan Wei, Shucheng Huidi, Huang Yingzhao, Jiang Xian
Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China.
Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.
Arch Dermatol Res. 2025 Feb 6;317(1):346. doi: 10.1007/s00403-024-03702-w.
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease associated with unique lesional dysbiotic features. However, the role of the microbiology in the pathogenesis of HS remains in dispute. We aimed to conduct a two-sample Mendelian randomization study to investigate the relationship between skin microbiota and HS. A two-sample Mendelian randomization study was performed using the summary statistics of skin microbiota from summary GWAS data of the European descent from two cross-sectional, population-based German cohorts, KORA FF4 (n = 324) and PopGen (n = 273). The summary statistics of hidradenitis suppurativa were obtained from the FinnGen DF10 (1,070 cases and 394,105 controls). Inverse variance weighted (IVW), MR-Egger regression, weighted median, simple mode, weighted mode, and MRPRESSO were used to examine the causal association between skin microbiota and hidradenitis suppurativa. Cochran's Q statistics were used to quantify the heterogeneity of instrumental variables. Our study suggested that genus Corynebacterium in dry skin is significantly associated with HS after false discovery rate (FDR) correction (odds ratio (OR) = 1.04, 95% confidence interval (CI): 1.02-1.06, P = 0.0002, FDR adjusted P = 0.035). Additionally, we found genus Micrococcus in moist skin (OR = 1.10, 95% CI: 1.03-1.18, P = 0.0060, FDR adjusted P = 0.360), species Streptococcus salivarius in dry skin (OR = 1.03, 95% CI: 1.01-1.05, P = 0.0070, FDR adjusted P = 0.360), and species Propionibacterium granulosum (OR = 1.02, 95% CI: 1.00-1.04, P = 0.0460, FDR adjusted P = 0.970) are potentially associated with HS before FDR adjustment. No evidence of the effect in the reverse direction for HS on skin microbial features. This two-sample Mendelian randomization study found that genus Corynebacterium was causally associated with HS. Further studies are needed to clarify the protective effect of prebiotics, probiotics or microbiome transplants on HS.
化脓性汗腺炎（HS）是一种与独特的皮损生态失调特征相关的慢性炎症性皮肤病。然而，微生物学在HS发病机制中的作用仍存在争议。我们旨在进行一项两样本孟德尔随机化研究，以探讨皮肤微生物群与HS之间的关系。使用来自两个基于人群的德国横断面队列（KORA FF4，n = 324；PopGen，n = 273）的欧洲血统汇总GWAS数据中的皮肤微生物群汇总统计数据，进行了一项两样本孟德尔随机化研究。化脓性汗腺炎的汇总统计数据来自芬兰基因库DF10（1070例病例和394105例对照）。采用逆方差加权（IVW）、MR-Egger回归、加权中位数、简单模式、加权模式和MRPRESSO来检验皮肤微生物群与化脓性汗腺炎之间的因果关联。使用 Cochr an Q统计量来量化工具变量的异质性。我们的研究表明，在错误发现率（FDR）校正后，干性皮肤中的棒状杆菌属与HS显著相关（优势比（OR）= 1.04，95%置信区间（CI）：1.02 - 1.06，P = 0.0002，FDR调整后P = 0.035）。此外，我们发现湿性皮肤中的微球菌属（OR = 1.10，95% CI：1.03 - 1.18，P = 0.0060，FDR调整后P = 0.360）、干性皮肤中的唾液链球菌种（OR = 1.03，95% CI：1.01 - 1.05，P = 0.0070，FDR调整后P = 0.360）以及颗粒丙酸杆菌种（OR = 1.02，95% CI：1.00 - 1.04，P = 0.0460，FDR调整后P = 0.970）在FDR调整前可能与HS相关。没有证据表明HS对皮肤微生物特征有反向影响。这项两样本孟德尔随机化研究发现棒状杆菌属与HS存在因果关联。需要进一步研究来阐明益生元、益生菌或微生物群移植对HS的保护作用。
